Expression Regulation and Function of T-Bet in NK Cells

Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is induced by cytokines such as IFN-γ, IL-12, IL-15...

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Detalles Bibliográficos
Autores principales: Huang, Chen, Bi, Jiacheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524037/
https://www.ncbi.nlm.nih.gov/pubmed/34675939
http://dx.doi.org/10.3389/fimmu.2021.761920
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author Huang, Chen
Bi, Jiacheng
author_facet Huang, Chen
Bi, Jiacheng
author_sort Huang, Chen
collection PubMed
description Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is induced by cytokines such as IFN-γ, IL-12, IL-15 and IL-21 through the respective cytokine receptors and downstream JAK/STATs or PI3K-AKT-mTORC1 signaling pathways. In this review, we aim to discuss the expression and regulation of T-bet in NK cells, the role of T-bet in mouse NK cell development, maturation, and function, as well as the role of T-bet in acute, chronic infection, inflammation, autoimmune diseases and tumors.
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spelling pubmed-85240372021-10-20 Expression Regulation and Function of T-Bet in NK Cells Huang, Chen Bi, Jiacheng Front Immunol Immunology Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is induced by cytokines such as IFN-γ, IL-12, IL-15 and IL-21 through the respective cytokine receptors and downstream JAK/STATs or PI3K-AKT-mTORC1 signaling pathways. In this review, we aim to discuss the expression and regulation of T-bet in NK cells, the role of T-bet in mouse NK cell development, maturation, and function, as well as the role of T-bet in acute, chronic infection, inflammation, autoimmune diseases and tumors. Frontiers Media S.A. 2021-10-05 /pmc/articles/PMC8524037/ /pubmed/34675939 http://dx.doi.org/10.3389/fimmu.2021.761920 Text en Copyright © 2021 Huang and Bi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Chen
Bi, Jiacheng
Expression Regulation and Function of T-Bet in NK Cells
title Expression Regulation and Function of T-Bet in NK Cells
title_full Expression Regulation and Function of T-Bet in NK Cells
title_fullStr Expression Regulation and Function of T-Bet in NK Cells
title_full_unstemmed Expression Regulation and Function of T-Bet in NK Cells
title_short Expression Regulation and Function of T-Bet in NK Cells
title_sort expression regulation and function of t-bet in nk cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524037/
https://www.ncbi.nlm.nih.gov/pubmed/34675939
http://dx.doi.org/10.3389/fimmu.2021.761920
work_keys_str_mv AT huangchen expressionregulationandfunctionoftbetinnkcells
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