A Comprehensive Review on the Role of Genetic Factors in Neuromyelitis Optica Spectrum Disorder

Neuromyelitis optica spectrum disorders (NMOSD) comprise a variety of disorders being described by optic neuritis and myelitis. This disorder is mostly observed in sporadic form, yet 3% of cases are familial NMO. Different series of familial NMO cases have been reported up to now, with some of them...

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Autores principales: Ghafouri-Fard, Soudeh, Azimi, Tahereh, Taheri, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524039/
https://www.ncbi.nlm.nih.gov/pubmed/34675927
http://dx.doi.org/10.3389/fimmu.2021.737673
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author Ghafouri-Fard, Soudeh
Azimi, Tahereh
Taheri, Mohammad
author_facet Ghafouri-Fard, Soudeh
Azimi, Tahereh
Taheri, Mohammad
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Neuromyelitis optica spectrum disorders (NMOSD) comprise a variety of disorders being described by optic neuritis and myelitis. This disorder is mostly observed in sporadic form, yet 3% of cases are familial NMO. Different series of familial NMO cases have been reported up to now, with some of them being associated with certain HLA haplotypes. Assessment of HLA allele and haplotypes has also revealed association between some alleles within HLA-DRB1 or other loci and sporadic NMO. More recently, genome-wide SNP arrays have shown some susceptibility loci for NMO. In the current manuscript, we review available information about the role of genetic factors in NMO.
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spelling pubmed-85240392021-10-20 A Comprehensive Review on the Role of Genetic Factors in Neuromyelitis Optica Spectrum Disorder Ghafouri-Fard, Soudeh Azimi, Tahereh Taheri, Mohammad Front Immunol Immunology Neuromyelitis optica spectrum disorders (NMOSD) comprise a variety of disorders being described by optic neuritis and myelitis. This disorder is mostly observed in sporadic form, yet 3% of cases are familial NMO. Different series of familial NMO cases have been reported up to now, with some of them being associated with certain HLA haplotypes. Assessment of HLA allele and haplotypes has also revealed association between some alleles within HLA-DRB1 or other loci and sporadic NMO. More recently, genome-wide SNP arrays have shown some susceptibility loci for NMO. In the current manuscript, we review available information about the role of genetic factors in NMO. Frontiers Media S.A. 2021-10-05 /pmc/articles/PMC8524039/ /pubmed/34675927 http://dx.doi.org/10.3389/fimmu.2021.737673 Text en Copyright © 2021 Ghafouri-Fard, Azimi and Taheri https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ghafouri-Fard, Soudeh
Azimi, Tahereh
Taheri, Mohammad
A Comprehensive Review on the Role of Genetic Factors in Neuromyelitis Optica Spectrum Disorder
title A Comprehensive Review on the Role of Genetic Factors in Neuromyelitis Optica Spectrum Disorder
title_full A Comprehensive Review on the Role of Genetic Factors in Neuromyelitis Optica Spectrum Disorder
title_fullStr A Comprehensive Review on the Role of Genetic Factors in Neuromyelitis Optica Spectrum Disorder
title_full_unstemmed A Comprehensive Review on the Role of Genetic Factors in Neuromyelitis Optica Spectrum Disorder
title_short A Comprehensive Review on the Role of Genetic Factors in Neuromyelitis Optica Spectrum Disorder
title_sort comprehensive review on the role of genetic factors in neuromyelitis optica spectrum disorder
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524039/
https://www.ncbi.nlm.nih.gov/pubmed/34675927
http://dx.doi.org/10.3389/fimmu.2021.737673
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