Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease

Chronic kidney disease (CKD) is associated with substantial morbidity and mortality. We developed a mouse model that mimics human CKD with inflammation, extracellular matrix deposition, tubulointerstitial fibrosis, increased proteinuria, and associated reduction in glomerular filtration rate over ti...

Descripción completa

Detalles Bibliográficos
Autores principales: Xin, Cuiyan, Lei, Jiahui, Wang, Qian, Yin, Yixia, Yang, Xiaoqian, Moran Guerrero, Jose Alberto, Sabbisetti, Venkata, Sun, Xiaoming, Vaidya, Vishal S., Bonventre, Joseph V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524153/
https://www.ncbi.nlm.nih.gov/pubmed/34703992
http://dx.doi.org/10.1016/j.isci.2021.103193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524153/
https://www.ncbi.nlm.nih.gov/pubmed/34703992
http://dx.doi.org/10.1016/j.isci.2021.103193

Ejemplares similares