Structural and biochemical insights into CRISPR RNA processing by the Cas5c ribonuclease SMU1763 from Streptococcus mutans

The cariogenic pathogen Streptococcus mutans contains two CRISPR systems (type I-C and type II-A) with the Cas5c protein (SmuCas5c) involved in processing of long CRISPR RNA transcripts (pre-crRNA) containing repeats and spacers to mature crRNA guides. In this study, we determined the crystal struct...

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Detalles Bibliográficos
Autores principales: Lemak, Sofia, Serbanescu, M. Anca, Khusnutdinova, Anna N., Ruszkowski, Milosz, Beloglazova, Natalia, Xu, Xiaohui, Brown, Greg, Cui, Hong, Tan, Kemin, Joachimiak, Andrzej, Cvitkovitch, Dennis G., Savchenko, Alexei, Yakunin, Alexander F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524198/
https://www.ncbi.nlm.nih.gov/pubmed/34592310
http://dx.doi.org/10.1016/j.jbc.2021.101251

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