Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings

We present autopsy findings of a 22-year-old man who developed chest pain 5 days after the first dose of the BNT162b2 mRNA vaccine and died 7 hours later. Histological examination of the heart revealed isolated atrial myocarditis, with neutrophil and histiocyte predominance. Immunohistochemical C4d...

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Autores principales: Choi, Sangjoon, Lee, SangHan, Seo, Jeong-Wook, Kim, Min-ju, Jeon, Yo Han, Park, Ji Hyun, Lee, Jong Kyu, Yeo, Nam Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524235/
https://www.ncbi.nlm.nih.gov/pubmed/34664804
http://dx.doi.org/10.3346/jkms.2021.36.e286
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author Choi, Sangjoon
Lee, SangHan
Seo, Jeong-Wook
Kim, Min-ju
Jeon, Yo Han
Park, Ji Hyun
Lee, Jong Kyu
Yeo, Nam Seok
author_facet Choi, Sangjoon
Lee, SangHan
Seo, Jeong-Wook
Kim, Min-ju
Jeon, Yo Han
Park, Ji Hyun
Lee, Jong Kyu
Yeo, Nam Seok
author_sort Choi, Sangjoon
collection PubMed
description We present autopsy findings of a 22-year-old man who developed chest pain 5 days after the first dose of the BNT162b2 mRNA vaccine and died 7 hours later. Histological examination of the heart revealed isolated atrial myocarditis, with neutrophil and histiocyte predominance. Immunohistochemical C4d staining revealed scattered single-cell necrosis of myocytes which was not accompanied by inflammatory infiltrates. Extensive contraction band necrosis was observed in the atria and ventricles. There was no evidence of microthrombosis or infection in the heart and other organs. The primary cause of death was determined to be myocarditis, causally-associated with the BNT162b2 vaccine.
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spelling pubmed-85242352021-10-29 Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings Choi, Sangjoon Lee, SangHan Seo, Jeong-Wook Kim, Min-ju Jeon, Yo Han Park, Ji Hyun Lee, Jong Kyu Yeo, Nam Seok J Korean Med Sci Case Report We present autopsy findings of a 22-year-old man who developed chest pain 5 days after the first dose of the BNT162b2 mRNA vaccine and died 7 hours later. Histological examination of the heart revealed isolated atrial myocarditis, with neutrophil and histiocyte predominance. Immunohistochemical C4d staining revealed scattered single-cell necrosis of myocytes which was not accompanied by inflammatory infiltrates. Extensive contraction band necrosis was observed in the atria and ventricles. There was no evidence of microthrombosis or infection in the heart and other organs. The primary cause of death was determined to be myocarditis, causally-associated with the BNT162b2 vaccine. The Korean Academy of Medical Sciences 2021-07-10 /pmc/articles/PMC8524235/ /pubmed/34664804 http://dx.doi.org/10.3346/jkms.2021.36.e286 Text en © 2021 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Choi, Sangjoon
Lee, SangHan
Seo, Jeong-Wook
Kim, Min-ju
Jeon, Yo Han
Park, Ji Hyun
Lee, Jong Kyu
Yeo, Nam Seok
Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings
title Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings
title_full Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings
title_fullStr Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings
title_full_unstemmed Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings
title_short Myocarditis-induced Sudden Death after BNT162b2 mRNA COVID-19 Vaccination in Korea: Case Report Focusing on Histopathological Findings
title_sort myocarditis-induced sudden death after bnt162b2 mrna covid-19 vaccination in korea: case report focusing on histopathological findings
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524235/
https://www.ncbi.nlm.nih.gov/pubmed/34664804
http://dx.doi.org/10.3346/jkms.2021.36.e286
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