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Examining the effects of prenatal alcohol exposure on corticothalamic connectivity: A multimodal neuroimaging study in children

Children with a fetal alcohol spectrum disorder (FASD) experience a range of cognitive and behavioral effects. Prior studies have demonstrated white matter changes in children with FASD relative to typically developing controls (TDC) and these changes relate to behavior. Our prior MEG study (Candela...

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Autores principales: Stephen, J.M., Hill, D.E., Candelaria-Cook, F.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524752/
https://www.ncbi.nlm.nih.gov/pubmed/34666262
http://dx.doi.org/10.1016/j.dcn.2021.101019
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author Stephen, J.M.
Hill, D.E.
Candelaria-Cook, F.T.
author_facet Stephen, J.M.
Hill, D.E.
Candelaria-Cook, F.T.
author_sort Stephen, J.M.
collection PubMed
description Children with a fetal alcohol spectrum disorder (FASD) experience a range of cognitive and behavioral effects. Prior studies have demonstrated white matter changes in children with FASD relative to typically developing controls (TDC) and these changes relate to behavior. Our prior MEG study (Candelaria-Cook et al. 2020) demonstrated reduced alpha oscillations during rest in FASD relative to TDC and alpha power is correlated with behavior. However, little is known about how brain structure influences brain function. We hypothesized that alpha power was related to corticothalamic connectivity. Children 8–13 years of age (TDC: N = 25, FASD: N = 24) underwent rest MEG with eyes open or closed and MRI to collect structural and diffusion tensor imaging data. MEG spectral analysis was performed for sensor and source data. We estimated mean fractional anisotropy in regions of interest (ROIs) that included the corticothalamic tracts. The FASD group had reduced mean FA in three of the corticothalamic ROIs. FA in these tracts was significantly correlated with alpha power at the sensor and source level. The results support the hypothesis that integrity of the corticothalamic tracts influences cortical alpha power. Further research is needed to understand how brain structure and function influence behavior.
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spelling pubmed-85247522021-10-25 Examining the effects of prenatal alcohol exposure on corticothalamic connectivity: A multimodal neuroimaging study in children Stephen, J.M. Hill, D.E. Candelaria-Cook, F.T. Dev Cogn Neurosci Original Research Children with a fetal alcohol spectrum disorder (FASD) experience a range of cognitive and behavioral effects. Prior studies have demonstrated white matter changes in children with FASD relative to typically developing controls (TDC) and these changes relate to behavior. Our prior MEG study (Candelaria-Cook et al. 2020) demonstrated reduced alpha oscillations during rest in FASD relative to TDC and alpha power is correlated with behavior. However, little is known about how brain structure influences brain function. We hypothesized that alpha power was related to corticothalamic connectivity. Children 8–13 years of age (TDC: N = 25, FASD: N = 24) underwent rest MEG with eyes open or closed and MRI to collect structural and diffusion tensor imaging data. MEG spectral analysis was performed for sensor and source data. We estimated mean fractional anisotropy in regions of interest (ROIs) that included the corticothalamic tracts. The FASD group had reduced mean FA in three of the corticothalamic ROIs. FA in these tracts was significantly correlated with alpha power at the sensor and source level. The results support the hypothesis that integrity of the corticothalamic tracts influences cortical alpha power. Further research is needed to understand how brain structure and function influence behavior. Elsevier 2021-10-08 /pmc/articles/PMC8524752/ /pubmed/34666262 http://dx.doi.org/10.1016/j.dcn.2021.101019 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Stephen, J.M.
Hill, D.E.
Candelaria-Cook, F.T.
Examining the effects of prenatal alcohol exposure on corticothalamic connectivity: A multimodal neuroimaging study in children
title Examining the effects of prenatal alcohol exposure on corticothalamic connectivity: A multimodal neuroimaging study in children
title_full Examining the effects of prenatal alcohol exposure on corticothalamic connectivity: A multimodal neuroimaging study in children
title_fullStr Examining the effects of prenatal alcohol exposure on corticothalamic connectivity: A multimodal neuroimaging study in children
title_full_unstemmed Examining the effects of prenatal alcohol exposure on corticothalamic connectivity: A multimodal neuroimaging study in children
title_short Examining the effects of prenatal alcohol exposure on corticothalamic connectivity: A multimodal neuroimaging study in children
title_sort examining the effects of prenatal alcohol exposure on corticothalamic connectivity: a multimodal neuroimaging study in children
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524752/
https://www.ncbi.nlm.nih.gov/pubmed/34666262
http://dx.doi.org/10.1016/j.dcn.2021.101019
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