Cargando…

Types of second primary cancer influence overall survival in cutaneous melanoma

BACKGROUND: Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and the type of SPC (second melanoma and other SPC) on overall survival. METHODS: W...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Guoqiao, Chattopadhyay, Subhayan, Sundquist, Kristina, Sundquist, Jan, Försti, Asta, Hemminki, Akseli, Hemminki, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524825/
https://www.ncbi.nlm.nih.gov/pubmed/34663263
http://dx.doi.org/10.1186/s12885-021-08845-x
_version_ 1784585553083105280
author Zheng, Guoqiao
Chattopadhyay, Subhayan
Sundquist, Kristina
Sundquist, Jan
Försti, Asta
Hemminki, Akseli
Hemminki, Kari
author_facet Zheng, Guoqiao
Chattopadhyay, Subhayan
Sundquist, Kristina
Sundquist, Jan
Försti, Asta
Hemminki, Akseli
Hemminki, Kari
author_sort Zheng, Guoqiao
collection PubMed
description BACKGROUND: Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and the type of SPC (second melanoma and other SPC) on overall survival. METHODS: We used the Swedish Cancer Registry data to assess overall survival in melanoma for the period 1990 to 2015. Kaplan-Meier curves were plotted and hazard ratios (HRs) were estimated with Cox regression models by considering SPC diagnosis as a time-dependent variable. RESULTS: A total of 46,726 patients were diagnosed with melanoma, and 15.3% of them developed SPC, among which, two thirds were other SPCs. Second melanomas were diagnosed early (31% during the first year) compared to non-melanoma SPCs (9.5%). Survival for women with second melanoma or other SPC (56 and 21% alive after 25 years of follow-up, respectively) exceeded the male rates (21 and 10%, respectively) but all these figures were lower than for females (60% alive) or males (48%) without SPC. Time dependent analysis showed vastly increased HRs for cancer types that are fatal also as first cancers, but SPC-specific HRs remained relatively uniform, irrespective of SPC diagnosed soon or late after first melanoma. In early-onset melanoma, SPC diagnosis after 10 years may not negatively influence overall survival. CONCLUSIONS: As the overall survival of patients with many types of SPCs is unfavorable, advice about health lifestyle should benefit smoking patients and early detection methods may be recommended for SPCs of the breast, prostate and colorectum. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08845-x.
format Online
Article
Text
id pubmed-8524825
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-85248252021-10-22 Types of second primary cancer influence overall survival in cutaneous melanoma Zheng, Guoqiao Chattopadhyay, Subhayan Sundquist, Kristina Sundquist, Jan Försti, Asta Hemminki, Akseli Hemminki, Kari BMC Cancer Research BACKGROUND: Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and the type of SPC (second melanoma and other SPC) on overall survival. METHODS: We used the Swedish Cancer Registry data to assess overall survival in melanoma for the period 1990 to 2015. Kaplan-Meier curves were plotted and hazard ratios (HRs) were estimated with Cox regression models by considering SPC diagnosis as a time-dependent variable. RESULTS: A total of 46,726 patients were diagnosed with melanoma, and 15.3% of them developed SPC, among which, two thirds were other SPCs. Second melanomas were diagnosed early (31% during the first year) compared to non-melanoma SPCs (9.5%). Survival for women with second melanoma or other SPC (56 and 21% alive after 25 years of follow-up, respectively) exceeded the male rates (21 and 10%, respectively) but all these figures were lower than for females (60% alive) or males (48%) without SPC. Time dependent analysis showed vastly increased HRs for cancer types that are fatal also as first cancers, but SPC-specific HRs remained relatively uniform, irrespective of SPC diagnosed soon or late after first melanoma. In early-onset melanoma, SPC diagnosis after 10 years may not negatively influence overall survival. CONCLUSIONS: As the overall survival of patients with many types of SPCs is unfavorable, advice about health lifestyle should benefit smoking patients and early detection methods may be recommended for SPCs of the breast, prostate and colorectum. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08845-x. BioMed Central 2021-10-19 /pmc/articles/PMC8524825/ /pubmed/34663263 http://dx.doi.org/10.1186/s12885-021-08845-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zheng, Guoqiao
Chattopadhyay, Subhayan
Sundquist, Kristina
Sundquist, Jan
Försti, Asta
Hemminki, Akseli
Hemminki, Kari
Types of second primary cancer influence overall survival in cutaneous melanoma
title Types of second primary cancer influence overall survival in cutaneous melanoma
title_full Types of second primary cancer influence overall survival in cutaneous melanoma
title_fullStr Types of second primary cancer influence overall survival in cutaneous melanoma
title_full_unstemmed Types of second primary cancer influence overall survival in cutaneous melanoma
title_short Types of second primary cancer influence overall survival in cutaneous melanoma
title_sort types of second primary cancer influence overall survival in cutaneous melanoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524825/
https://www.ncbi.nlm.nih.gov/pubmed/34663263
http://dx.doi.org/10.1186/s12885-021-08845-x
work_keys_str_mv AT zhengguoqiao typesofsecondprimarycancerinfluenceoverallsurvivalincutaneousmelanoma
AT chattopadhyaysubhayan typesofsecondprimarycancerinfluenceoverallsurvivalincutaneousmelanoma
AT sundquistkristina typesofsecondprimarycancerinfluenceoverallsurvivalincutaneousmelanoma
AT sundquistjan typesofsecondprimarycancerinfluenceoverallsurvivalincutaneousmelanoma
AT forstiasta typesofsecondprimarycancerinfluenceoverallsurvivalincutaneousmelanoma
AT hemminkiakseli typesofsecondprimarycancerinfluenceoverallsurvivalincutaneousmelanoma
AT hemminkikari typesofsecondprimarycancerinfluenceoverallsurvivalincutaneousmelanoma