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Types of second primary cancer influence overall survival in cutaneous melanoma
BACKGROUND: Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and the type of SPC (second melanoma and other SPC) on overall survival. METHODS: W...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524825/ https://www.ncbi.nlm.nih.gov/pubmed/34663263 http://dx.doi.org/10.1186/s12885-021-08845-x |
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author | Zheng, Guoqiao Chattopadhyay, Subhayan Sundquist, Kristina Sundquist, Jan Försti, Asta Hemminki, Akseli Hemminki, Kari |
author_facet | Zheng, Guoqiao Chattopadhyay, Subhayan Sundquist, Kristina Sundquist, Jan Försti, Asta Hemminki, Akseli Hemminki, Kari |
author_sort | Zheng, Guoqiao |
collection | PubMed |
description | BACKGROUND: Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and the type of SPC (second melanoma and other SPC) on overall survival. METHODS: We used the Swedish Cancer Registry data to assess overall survival in melanoma for the period 1990 to 2015. Kaplan-Meier curves were plotted and hazard ratios (HRs) were estimated with Cox regression models by considering SPC diagnosis as a time-dependent variable. RESULTS: A total of 46,726 patients were diagnosed with melanoma, and 15.3% of them developed SPC, among which, two thirds were other SPCs. Second melanomas were diagnosed early (31% during the first year) compared to non-melanoma SPCs (9.5%). Survival for women with second melanoma or other SPC (56 and 21% alive after 25 years of follow-up, respectively) exceeded the male rates (21 and 10%, respectively) but all these figures were lower than for females (60% alive) or males (48%) without SPC. Time dependent analysis showed vastly increased HRs for cancer types that are fatal also as first cancers, but SPC-specific HRs remained relatively uniform, irrespective of SPC diagnosed soon or late after first melanoma. In early-onset melanoma, SPC diagnosis after 10 years may not negatively influence overall survival. CONCLUSIONS: As the overall survival of patients with many types of SPCs is unfavorable, advice about health lifestyle should benefit smoking patients and early detection methods may be recommended for SPCs of the breast, prostate and colorectum. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08845-x. |
format | Online Article Text |
id | pubmed-8524825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85248252021-10-22 Types of second primary cancer influence overall survival in cutaneous melanoma Zheng, Guoqiao Chattopadhyay, Subhayan Sundquist, Kristina Sundquist, Jan Försti, Asta Hemminki, Akseli Hemminki, Kari BMC Cancer Research BACKGROUND: Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and the type of SPC (second melanoma and other SPC) on overall survival. METHODS: We used the Swedish Cancer Registry data to assess overall survival in melanoma for the period 1990 to 2015. Kaplan-Meier curves were plotted and hazard ratios (HRs) were estimated with Cox regression models by considering SPC diagnosis as a time-dependent variable. RESULTS: A total of 46,726 patients were diagnosed with melanoma, and 15.3% of them developed SPC, among which, two thirds were other SPCs. Second melanomas were diagnosed early (31% during the first year) compared to non-melanoma SPCs (9.5%). Survival for women with second melanoma or other SPC (56 and 21% alive after 25 years of follow-up, respectively) exceeded the male rates (21 and 10%, respectively) but all these figures were lower than for females (60% alive) or males (48%) without SPC. Time dependent analysis showed vastly increased HRs for cancer types that are fatal also as first cancers, but SPC-specific HRs remained relatively uniform, irrespective of SPC diagnosed soon or late after first melanoma. In early-onset melanoma, SPC diagnosis after 10 years may not negatively influence overall survival. CONCLUSIONS: As the overall survival of patients with many types of SPCs is unfavorable, advice about health lifestyle should benefit smoking patients and early detection methods may be recommended for SPCs of the breast, prostate and colorectum. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08845-x. BioMed Central 2021-10-19 /pmc/articles/PMC8524825/ /pubmed/34663263 http://dx.doi.org/10.1186/s12885-021-08845-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zheng, Guoqiao Chattopadhyay, Subhayan Sundquist, Kristina Sundquist, Jan Försti, Asta Hemminki, Akseli Hemminki, Kari Types of second primary cancer influence overall survival in cutaneous melanoma |
title | Types of second primary cancer influence overall survival in cutaneous melanoma |
title_full | Types of second primary cancer influence overall survival in cutaneous melanoma |
title_fullStr | Types of second primary cancer influence overall survival in cutaneous melanoma |
title_full_unstemmed | Types of second primary cancer influence overall survival in cutaneous melanoma |
title_short | Types of second primary cancer influence overall survival in cutaneous melanoma |
title_sort | types of second primary cancer influence overall survival in cutaneous melanoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524825/ https://www.ncbi.nlm.nih.gov/pubmed/34663263 http://dx.doi.org/10.1186/s12885-021-08845-x |
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