Dual inhibition of α(v)β(6) and α(v)β(1) reduces fibrogenesis in lung tissue explants from patients with IPF

RATIONALE: α(v) integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (α(v)β(6)) and fibroblasts (α(v)β(1)) in fibrotic lungs. OBJECTIVES: We evaluated multiple α(v) integrin inhibitio...

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Detalles Bibliográficos
Autores principales: Decaris, Martin L., Schaub, Johanna R., Chen, Chun, Cha, Jacob, Lee, Gail G., Rexhepaj, Megi, Ho, Steve S., Rao, Vikram, Marlow, Megan M., Kotak, Prerna, Budi, Erine H., Hooi, Lisa, Wu, Jianfeng, Fridlib, Marina, Martin, Shamra P., Huang, Shaoyi, Chen, Ming, Muñoz, Manuel, Hom, Timothy F., Wolters, Paul J., Desai, Tushar J., Rock, Fernando, Leftheris, Katerina, Morgans, David J., Lepist, Eve-Irene, Andre, Patrick, Lefebvre, Eric A., Turner, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524858/
https://www.ncbi.nlm.nih.gov/pubmed/34666752
http://dx.doi.org/10.1186/s12931-021-01863-0

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