Urine volume to hydration volume ratio is associated with pharmacokinetics of high‐dose methotrexate in patients with primary central nervous system lymphoma

High‐dose methotrexate (HD‐MTX)‐based chemotherapy is the first‐line treatment for primary central nervous system lymphoma (PCNSL), but is associated with severe adverse effects, including myelosuppression and renal impairment. MTX is primarily excreted by the kidneys. Renal function calculated usin...

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Detalles Bibliográficos
Autores principales: Isono, Tetsuichiro, Hira, Daiki, Morikochi, Aya, Fukami, Tadateru, Ueshima, Satoshi, Nozaki, Kazuhiko, Terada, Tomohiro, Morita, Shin‐ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525095/
https://www.ncbi.nlm.nih.gov/pubmed/34664791
http://dx.doi.org/10.1002/prp2.883

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