Pseudoprogression of Malignant Peripheral Nerve Sheath Tumor in Patient with Neurofibromatosis Type 1, a Case Report

Pseudoprogression, defined as the radiographic false appearance of disease progression, is not frequently observed in patients with malignant peripheral nerve sheath tumor (MPNST). We report on a case of a patient with neurofibromatosis type 1 (NF1) MPNST pseudoprogression that presented as suspecte...

Descripción completa

Detalles Bibliográficos
Autores principales: Lessing, Andrés J., Cote, Gregory M., DeLaney, Thomas F., Plotkin, Scott R., Raskin, Kevin A., Lessing, Juan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525267/
https://www.ncbi.nlm.nih.gov/pubmed/34720939
http://dx.doi.org/10.1159/000518317
_version_ 1784585653860696064
author Lessing, Andrés J.
Cote, Gregory M.
DeLaney, Thomas F.
Plotkin, Scott R.
Raskin, Kevin A.
Lessing, Juan N.
author_facet Lessing, Andrés J.
Cote, Gregory M.
DeLaney, Thomas F.
Plotkin, Scott R.
Raskin, Kevin A.
Lessing, Juan N.
author_sort Lessing, Andrés J.
collection PubMed
description Pseudoprogression, defined as the radiographic false appearance of disease progression, is not frequently observed in patients with malignant peripheral nerve sheath tumor (MPNST). We report on a case of a patient with neurofibromatosis type 1 (NF1) MPNST pseudoprogression that presented as suspected local recurrence 9.5 years after last treatment. The patient underwent surgical resection following growth of a mass on sequential MRI imaging; surgical pathology, however, showed skeletal muscle with atrophy, fibroadipose tissue, and fat necrosis, without any evidence of tumor. As MPNST survival rates increase, physicians should consider pseudoprogression as a potential presentation after prior treatment.
format Online
Article
Text
id pubmed-8525267
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-85252672021-10-28 Pseudoprogression of Malignant Peripheral Nerve Sheath Tumor in Patient with Neurofibromatosis Type 1, a Case Report Lessing, Andrés J. Cote, Gregory M. DeLaney, Thomas F. Plotkin, Scott R. Raskin, Kevin A. Lessing, Juan N. Case Rep Oncol Case Report Pseudoprogression, defined as the radiographic false appearance of disease progression, is not frequently observed in patients with malignant peripheral nerve sheath tumor (MPNST). We report on a case of a patient with neurofibromatosis type 1 (NF1) MPNST pseudoprogression that presented as suspected local recurrence 9.5 years after last treatment. The patient underwent surgical resection following growth of a mass on sequential MRI imaging; surgical pathology, however, showed skeletal muscle with atrophy, fibroadipose tissue, and fat necrosis, without any evidence of tumor. As MPNST survival rates increase, physicians should consider pseudoprogression as a potential presentation after prior treatment. S. Karger AG 2021-09-20 /pmc/articles/PMC8525267/ /pubmed/34720939 http://dx.doi.org/10.1159/000518317 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Lessing, Andrés J.
Cote, Gregory M.
DeLaney, Thomas F.
Plotkin, Scott R.
Raskin, Kevin A.
Lessing, Juan N.
Pseudoprogression of Malignant Peripheral Nerve Sheath Tumor in Patient with Neurofibromatosis Type 1, a Case Report
title Pseudoprogression of Malignant Peripheral Nerve Sheath Tumor in Patient with Neurofibromatosis Type 1, a Case Report
title_full Pseudoprogression of Malignant Peripheral Nerve Sheath Tumor in Patient with Neurofibromatosis Type 1, a Case Report
title_fullStr Pseudoprogression of Malignant Peripheral Nerve Sheath Tumor in Patient with Neurofibromatosis Type 1, a Case Report
title_full_unstemmed Pseudoprogression of Malignant Peripheral Nerve Sheath Tumor in Patient with Neurofibromatosis Type 1, a Case Report
title_short Pseudoprogression of Malignant Peripheral Nerve Sheath Tumor in Patient with Neurofibromatosis Type 1, a Case Report
title_sort pseudoprogression of malignant peripheral nerve sheath tumor in patient with neurofibromatosis type 1, a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525267/
https://www.ncbi.nlm.nih.gov/pubmed/34720939
http://dx.doi.org/10.1159/000518317
work_keys_str_mv AT lessingandresj pseudoprogressionofmalignantperipheralnervesheathtumorinpatientwithneurofibromatosistype1acasereport
AT cotegregorym pseudoprogressionofmalignantperipheralnervesheathtumorinpatientwithneurofibromatosistype1acasereport
AT delaneythomasf pseudoprogressionofmalignantperipheralnervesheathtumorinpatientwithneurofibromatosistype1acasereport
AT plotkinscottr pseudoprogressionofmalignantperipheralnervesheathtumorinpatientwithneurofibromatosistype1acasereport
AT raskinkevina pseudoprogressionofmalignantperipheralnervesheathtumorinpatientwithneurofibromatosistype1acasereport
AT lessingjuann pseudoprogressionofmalignantperipheralnervesheathtumorinpatientwithneurofibromatosistype1acasereport

Ejemplares similares