Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report

Primary CNS lymphoma (PCNSL) is a highly aggressive malignant disease with a high recurrence rate and a poor prognosis. We present the case of a 71-year-old woman diagnosed with PCNSL in June 2010. After 3 relapses and intensive treatment with multiple chemotherapy regimens and whole-brain radiother...

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Autores principales: Mair, Anna, Muigg, Armin, Stockhammer, Günther, Mangesius, Stephanie, Wolf, Dominik, Gunsilius, Eberhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525268/
https://www.ncbi.nlm.nih.gov/pubmed/34720938
http://dx.doi.org/10.1159/000518528
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author Mair, Anna
Muigg, Armin
Stockhammer, Günther
Mangesius, Stephanie
Wolf, Dominik
Gunsilius, Eberhard
author_facet Mair, Anna
Muigg, Armin
Stockhammer, Günther
Mangesius, Stephanie
Wolf, Dominik
Gunsilius, Eberhard
author_sort Mair, Anna
collection PubMed
description Primary CNS lymphoma (PCNSL) is a highly aggressive malignant disease with a high recurrence rate and a poor prognosis. We present the case of a 71-year-old woman diagnosed with PCNSL in June 2010. After 3 relapses and intensive treatment with multiple chemotherapy regimens and whole-brain radiotherapy, she received off-label treatment with the Bruton tyrosine kinase inhibitor ibrutinib, responded well, achieved a complete remission, and is progression-free for now >3 years.
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spelling pubmed-85252682021-10-28 Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report Mair, Anna Muigg, Armin Stockhammer, Günther Mangesius, Stephanie Wolf, Dominik Gunsilius, Eberhard Case Rep Oncol Case Report Primary CNS lymphoma (PCNSL) is a highly aggressive malignant disease with a high recurrence rate and a poor prognosis. We present the case of a 71-year-old woman diagnosed with PCNSL in June 2010. After 3 relapses and intensive treatment with multiple chemotherapy regimens and whole-brain radiotherapy, she received off-label treatment with the Bruton tyrosine kinase inhibitor ibrutinib, responded well, achieved a complete remission, and is progression-free for now >3 years. S. Karger AG 2021-09-20 /pmc/articles/PMC8525268/ /pubmed/34720938 http://dx.doi.org/10.1159/000518528 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Mair, Anna
Muigg, Armin
Stockhammer, Günther
Mangesius, Stephanie
Wolf, Dominik
Gunsilius, Eberhard
Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report
title Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report
title_full Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report
title_fullStr Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report
title_full_unstemmed Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report
title_short Sustained Complete Remission in Multi-Relapsed Primary CNS Lymphoma Treated with Ibrutinib Monotherapy: A Case Report
title_sort sustained complete remission in multi-relapsed primary cns lymphoma treated with ibrutinib monotherapy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525268/
https://www.ncbi.nlm.nih.gov/pubmed/34720938
http://dx.doi.org/10.1159/000518528
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