Cargando…

Case Report: Sustained Remission Due to PD-1-Inhibition in a Metastatic Melanoma Patient With Depleted B Cells

INTRODUCTION: Checkpoint-Inhibition (CPI) with PD-1- and PD-L1-inhibitors is a well-established therapy for advanced stage melanoma patients. CPI mainly acts via T-lymphocytes. However, recent literature suggests also a role for B cells modulating its efficacy and tolerability of CPI. CASE REPORT: W...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wulfken, Lena Margarethe, Becker, Jürgen Christian, Hayajneh, Rami, Wagner, Annette Doris, Schaper-Gerhardt, Katrin, Flatt, Nina, Grimmelmann, Imke, Gutzmer, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525286/ https://www.ncbi.nlm.nih.gov/pubmed/34675925 http://dx.doi.org/10.3389/fimmu.2021.733961

Ejemplares similares

Histamine Increases Th2 Cytokine-Induced CCL18 Expression in Human M2 Macrophages
por: Mommert, Susanne, et al.
Publicado: (2021)

Histamine up‐regulates oncostatin M expression in human M1 macrophages
por: Mommert, Susanne, et al.
Publicado: (2019)

Histamine Activates Human Eosinophils via H(2)R and H(4)R Predominantly in Atopic Dermatitis Patients
por: Beyer, Leonie, et al.
Publicado: (2022)

Immunogenicity of COVID-19 Vaccination in Melanoma Patients under Immune Checkpoint Blockade
por: Niewolik, Jacqueline, et al.
Publicado: (2022)

Clinics, prognosis and new therapeutic options in patients with mucosal melanoma: A retrospective analysis of 75 patients
por: Schaefer, Tim, et al.
Publicado: (2017)

Reinduction of Hedgehog Inhibitors after Checkpoint Inhibition in Advanced Basal Cell Carcinoma: A Series of 12 Patients
por: DeTemple, Viola K., et al.
Publicado: (2022)

Anti‐PD‐1 antibodies in metastatic uveal melanoma: a treatment option?
por: Bender, Carolin, et al.
Publicado: (2017)

Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis
por: ROSSBACH, Kristine, et al.
Publicado: (2020)

Allele frequencies of BRAFV600 mutations in primary melanomas and matched metastases and their relevance for BRAF inhibitor therapy in metastatic melanoma
por: Satzger, Imke, et al.
Publicado: (2015)

Monocyte chemoattractant protein 1 as a potential biomarker for immune checkpoint inhibitor‐associated neurotoxicity
por: Möhn, Nora, et al.
Publicado: (2023)

Digital Quantification of Tumor PD-L1 Predicts Outcome of PD-1-Based Immune Checkpoint Therapy in Metastatic Melanoma
por: Placke, Jan-Malte, et al.
Publicado: (2021)

Neurological Immune Related Adverse Events Associated with Nivolumab, Ipilimumab, and Pembrolizumab Therapy—Review of the Literature and Future Outlook
por: Möhn, Nora, et al.
Publicado: (2019)

Risk Factors for Developing Nonmelanoma Skin Cancer after Lung Transplantation
por: Gräger, Nikolai, et al.
Publicado: (2019)

Impact of the COVID‐19 pandemic on the care of patients with malignant melanoma
por: Welzel, Julia, et al.
Publicado: (2022)

Medical Needs and Therapeutic Options for Melanoma Patients Resistant to Anti-PD-1-Directed Immune Checkpoint Inhibition
por: Hassel, Jessica C., et al.
Publicado: (2023)

Factors Influencing the Adjuvant Therapy Decision: Results of a Real-World Multicenter Data Analysis of 904 Melanoma Patients
por: Lodde, Georg, et al.
Publicado: (2021)

Depletion of PD-1-positive cells ameliorates autoimmune disease
por: Zhao, Peng, et al.
Publicado: (2019)

SARS-CoV-2 infections in melanoma patients treated with PD-1 inhibitors: A survey of the German ADOREG melanoma registry
por: Moritz, Rose K.C., et al.
Publicado: (2021)

Clinical and molecular characteristics associated with response to therapeutic PD-1/PD-L1 inhibition in advanced Merkel cell carcinoma
por: Spassova, Ivelina, et al.
Publicado: (2022)

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway
por: Fife, Brian T., et al.
Publicado: (2006)

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
por: Liu, David, et al.
Publicado: (2019)

Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients
por: Kretschmer, Lutz, et al.
Publicado: (2015)

Depletion of PD-1 or PD-L1 did not affect the mortality of mice infected with Mycobacterium avium
por: Nakajima, Masayuki, et al.
Publicado: (2021)

Correlation of tumor PD-L1 expression in different tissue types and outcome of PD-1-based immunotherapy in metastatic melanoma – analysis of the DeCOG prospective multicenter cohort study ADOREG/TRIM
por: Placke, Jan-Malte, et al.
Publicado: (2023)

Soziale Teilhabe und Hautkrebs während der COVID-19-Pandemie
por: Niewolik, Jacqueline, et al.
Publicado: (2023)

Sustaining remission of psychotic depression: rationale, design and methodology of STOP-PD ΙΙ
por: Flint, Alastair J, et al.
Publicado: (2013)

Outcomes following second allogeneic stem cell transplant for disease relapse after T cell depleted transplant correlate with remission status and remission duration after the first transplant
por: Fan, Yun, et al.
Publicado: (2019)

Neutrophil depletion enhances the therapeutic effect of PD-1 antibody on glioma
por: Wang, Peng-Fei, et al.
Publicado: (2020)

Triple Combination of Immune Checkpoint Inhibitors and BRAF/MEK Inhibitors in BRAFV600 Melanoma: Current Status and Future Perspectives
por: Welti, Michèle, et al.
Publicado: (2022)

Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
por: Liu, David, et al.
Publicado: (2020)

Real-World Therapy with Pembrolizumab: Outcomes and Surrogate Endpoints for Predicting Survival in Advanced Melanoma Patients in Germany
por: Mohr, Peter, et al.
Publicado: (2022)

PD-L1(ATTAC) mice reveal the potential of depleting PD-L1 expressing cells in cancer therapy
por: Fueyo-Marcos, Elena, et al.
Publicado: (2023)

MicroRNAs in Renal Cell Carcinoma: Diagnostic Implications of Serum miR-1233 Levels
por: Wulfken, Lena M., et al.
Publicado: (2011)

The effect of deep or sustained remission on maintenance of remission after dose reduction or withdrawal of etanercept in patients with rheumatoid arthritis
por: Tanaka, Yoshiya, et al.
Publicado: (2019)

Evolution characteristics of dynamic balance disorder over the course of PD and relationship with dopamine depletion
por: Gan, Jing, et al.
Publicado: (2023)

Diagnosis and Differential Diagnosis of Neurological Adverse Events during Immune Checkpoint Inhibitor Therapy
por: Möhn, Nora, et al.
Publicado: (2020)

Chemosensitivity-directed therapy compared to dacarbazine in chemo-naive advanced metastatic melanoma: a multicenter randomized phase-3 DeCOG trial
por: Ugurel, Selma, et al.
Publicado: (2017)

Auswirkungen der COVID‐19‐Pandemie auf die Versorgung von Patienten mit malignem Melanom
por: Welzel, Julia, et al.
Publicado: (2022)

PD-1/CTLA-4 Blockade Leads to Expansion of CD8(+)PD-1(int) TILs and Results in Tumor Remission in Experimental Liver Cancer
por: Bufe, Sandra, et al.
Publicado: (2022)

PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia
por: Dey, Parama, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_scdh5svfmsn3cimafrpecm7sj1