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Genetic and Epigenetic Therapies for β-Thalassaemia by Altering the Expression of α-Globin Gene
β-Thalassaemia is caused by over 300 mutations in and around the β-globin gene that lead to impaired synthesis of β-globin. The expression of α-globin continues normally, resulting in an excess of α-globin chains within red blood cells and their precursors. These unpaired α-globin chains form unstab...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525347/ https://www.ncbi.nlm.nih.gov/pubmed/34713267 http://dx.doi.org/10.3389/fgeed.2021.752278 |