Cargando…

Genomic Engineering in Human Hematopoietic Stem Cells: Hype or Hope?

Many gene editing techniques are developed and tested, yet, most of these are optimized for transformed cell lines, which differ from their primary cell counterparts in terms of transfectability, cell death propensity, differentiation capability, and chromatin accessibility to gene editing tools. Re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klaver-Flores, Stefanie, Zittersteijn, Hidde A., Canté-Barrett, Kirsten, Lankester, Arjan, Hoeben, Rob C., Gonçalves, Manuel A. F. V., Pike-Overzet, Karin, Staal, Frank J. T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genome Editing
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525357/ https://www.ncbi.nlm.nih.gov/pubmed/34713237 http://dx.doi.org/10.3389/fgeed.2020.615619

Ejemplares similares

A Small Key for a Heavy Door: Genetic Therapies for the Treatment of Hemoglobinopathies
por: Zittersteijn, Hidde A., et al.
Publicado: (2021)

Preclinical Development of Autologous Hematopoietic Stem Cell-Based Gene Therapy for Immune Deficiencies: A Journey from Mouse Cage to Bed Side
por: Garcia-Perez, Laura, et al.
Publicado: (2020)

Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?
por: Jridi, Imen, et al.
Publicado: (2021)

Stem Cell-Based Disease Models for Inborn Errors of Immunity
por: Zbinden, Aline, et al.
Publicado: (2021)

Gene Editing of Hematopoietic Stem Cells: Hopes and Hurdles Toward Clinical Translation
por: Ferrari, Samuele, et al.
Publicado: (2021)

Combining Mobilizing Agents with Busulfan to Reduce Chemotherapy-Based Conditioning for Hematopoietic Stem Cell Transplantation
por: Garcia-Perez, Laura, et al.
Publicado: (2021)

Multi-omic analyses in immune cell development with lessons learned from T cell development
por: Cordes, Martijn, et al.
Publicado: (2023)

The Promise and the Hope of Gene Therapy
por: Papanikolaou, Eleni, et al.
Publicado: (2021)

Hope and hype
por: De Clercq, Erik
Publicado: (2006)

IL3 Has a Detrimental Effect on Hematopoietic Stem Cell Self-Renewal in Transplantation Settings
por: Tajer, Parisa, et al.
Publicado: (2022)

A primer to gene therapy: Progress, prospects, and problems
por: Zittersteijn, Hidde A., et al.
Publicado: (2020)

The quest for the holy grail: overcoming challenges in expanding human hematopoietic stem cells for clinical use
por: Bastani, Sepideh, et al.
Publicado: (2023)

Cytokines in Schizophrenia: Hope or Hype?
por: Koola, Maju Mathew
Publicado: (2016)

Probiotic Supplements: Hope or Hype?
por: Wang, Yuxuan, et al.
Publicado: (2020)

Hematopoietic stem and progenitors cells gene editing: Beyond blood disorders
por: Buffa, Valentina, et al.
Publicado: (2023)

Loss of CD44(dim) Expression from Early Progenitor Cells Marks T-Cell Lineage Commitment in the Human Thymus
por: Canté-Barrett, Kirsten, et al.
Publicado: (2017)

Ex Vivo Expansion of Hematopoietic Stem Cells for Therapeutic Purposes: Lessons from Development and the Niche
por: Tajer, Parisa, et al.
Publicado: (2019)

Nanoparticles targeting hematopoietic stem and progenitor cells: Multimodal carriers for the treatment of hematological diseases
por: Cruz, Luis J., et al.
Publicado: (2022)

Current approaches and potential challenges in the delivery of gene editing cargos into hematopoietic stem and progenitor cells
por: Murugesan, Ramya, et al.
Publicado: (2023)

Microarrays for Bacterial Pathogens — Hope or Hype?
por: Wren, Brendan W.
Publicado: (2002)

PCR for the diagnosis of sepsis: hope or hype?
por: Schrenzel, Jacques
Publicado: (2011)

Schedule H1: Hope or hype?
por: Hazra, Avijit
Publicado: (2014)

Nilotinib – Differentiating the Hope from the Hype
por: Wyse, Richard K., et al.
Publicado: (2016)

The Gut and Parkinson’s Disease: Hype or Hope?
por: Scheperjans, Filip, et al.
Publicado: (2018)

Blockchain in Health Care: Hope or Hype?
por: El-Gazzar, Rania, et al.
Publicado: (2020)

The Hype and Hope of Stem Cell Rejuvenation
por: Harris, Melissa
Publicado: (2020)

Colchicine for COVID-19: Hype or hope?
por: Kow, Chia Siang, et al.
Publicado: (2022)

Suicide prevention in Bangladesh: Hope and hype
por: Farahat, Ramadan Abdelmoez, et al.
Publicado: (2022)

Plant Microbiome Engineering: Hopes or Hypes
por: Afridi, Muhammad Siddique, et al.
Publicado: (2022)

Prime editing in hematopoietic stem cells—From ex vivo to in vivo CRISPR-based treatment of blood disorders
por: Wolff, Jonas Holst, et al.
Publicado: (2023)

Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components
por: Maggio, Ignazio, et al.
Publicado: (2020)

Global and Local Manipulation of DNA Repair Mechanisms to Alter Site-Specific Gene Editing Outcomes in Hematopoietic Stem Cells
por: Benitez, Elizabeth K., et al.
Publicado: (2020)

High-efficiency editing in hematopoietic stem cells and the HUDEP-2 cell line based on in vitro mRNA synthesis
por: Papaioannou, Nikoletta Y., et al.
Publicado: (2023)

Drug design for ever, from hype to hope
por: Seddon, G., et al.
Publicado: (2012)

NgAgo: a hope or a hype?
por: Zhang, Xiaoxue
Publicado: (2016)

Add-ons in IVF programme – Hype or Hope?
por: Datta, AK, et al.
Publicado: (2015)

Regenerative Medicine in Aesthetic Surgery: Hope or Hype?
por: Khunger, Niti
Publicado: (2014)

The Hoops, Hopes, and Hypes of Human Microbiome Research
por: Bik, Elisabeth M.
Publicado: (2016)

Intervertebral Disc Nucleus Repair: Hype or Hope?
por: Tendulkar, Gauri, et al.
Publicado: (2019)

Gene Therapy in Hemophilia: From Hype to Hope
por: Schutgens, Roger
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_31c95cvodsuo6td046osq9ahvk