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Off-Target Analysis in Gene Editing and Applications for Clinical Translation of CRISPR/Cas9 in HIV-1 Therapy

As genome-editing nucleases move toward broader clinical applications, the need to define the limits of their specificity and efficiency increases. A variety of approaches for nuclease cleavage detection have been developed, allowing a full-genome survey of the targeting landscape and the detection...

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Detalles Bibliográficos
Autores principales:	Atkins, Andrew, Chung, Cheng-Han, Allen, Alexander G., Dampier, Will, Gurrola, Theodore E., Sariyer, Ilker K., Nonnemacher, Michael R., Wigdahl, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genome Editing
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525399/ https://www.ncbi.nlm.nih.gov/pubmed/34713260 http://dx.doi.org/10.3389/fgeed.2021.673022

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