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Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2

Iron regulatory protein 2 (IRP2) deficiency in mice and humans causes microcytic anemia and neurodegeneration due to functional cellular iron depletion. Our previous in vitro data have demonstrated that Irp2 depletion upregulates hypoxia-inducible factor subunits Hif1α and Hif2α expression; inhibiti...

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Detalles Bibliográficos
Autores principales:	Shen, Jiaqi, Xu, Li, Li, Yuxuan, Dong, Weichen, Cai, Jing, Liu, Yutong, Zhao, Hongting, Xu, Tianze, Holtz, Esther Meyron, Chang, Yanzhong, Qiao, Tong, Li, Kuanyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525628/ https://www.ncbi.nlm.nih.gov/pubmed/34675764 http://dx.doi.org/10.3389/fnins.2021.715222

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