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Therapeutic MK2 inhibition blocks pathological vascular smooth muscle cell phenotype switch

Vascular procedures, such as stenting, angioplasty, and bypass grafting, often fail due to intimal hyperplasia (IH), wherein contractile vascular smooth muscle cells (VSMCs) dedifferentiate to synthetic VSMCs, which are highly proliferative, migratory, and fibrotic. Previous studies suggest MAPK-act...

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Detalles Bibliográficos
Autores principales:	Tierney, J. William, Evans, Brian C., Cheung-Flynn, Joyce, Wang, Bo, Colazo, Juan M., Polcz, Monica E., Cook, Rebecca S., Brophy, Colleen M., Duvall, Craig L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525639/ https://www.ncbi.nlm.nih.gov/pubmed/34622803 http://dx.doi.org/10.1172/jci.insight.142339

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