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Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression

A population genetic study identified that the asialoglycoprotein receptor 1 (ASGR1) mutation carriers had substantially lower non–HDL-cholesterol (non–HDL-c) levels and reduced risks of cardiovascular diseases. However, the mechanism behind this phenomenon remained unclear. Here, we established Asg...

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Detalles Bibliográficos
Autores principales:	Xu, Yingying, Tao, Jiawang, Yu, Xiaorui, Wu, Yuhang, Chen, Yan, You, Kai, Zhang, Jiaye, Getachew, Anteneh, Pan, Tingcai, Zhuang, Yuanqi, Yuan, Fang, Yang, Fan, Lin, Xianhua, Li, Yin-xiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525641/ https://www.ncbi.nlm.nih.gov/pubmed/34622799 http://dx.doi.org/10.1172/jci.insight.147038

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