AMPK mediates regulation of glomerular volume and podocyte survival

Herein, we report that Shroom3 knockdown, via Fyn inhibition, induced albuminuria with foot process effacement (FPE) without focal segmental glomerulosclerosis (FSGS) or podocytopenia. Interestingly, knockdown mice had reduced podocyte volumes. Human minimal change disease (MCD), where podocyte Fyn...

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Detalles Bibliográficos
Autores principales: Banu, Khadija, Lin, Qisheng, Basgen, John M., Planoutene, Marina, Wei, Chengguo, Reghuvaran, Anand C., Tian, Xuefei, Shi, Hongmei, Garzon, Felipe, Garzia, Aitor, Chun, Nicholas, Cumpelik, Arun, Santeusanio, Andrew D., Zhang, Weijia, Das, Bhaskar, Salem, Fadi, Li, Li, Ishibe, Shuta, Cantley, Lloyd G., Kaufman, Lewis, Lemley, Kevin V., Ni, Zhaohui, He, John Cijiang, Murphy, Barbara, Menon, Madhav C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525649/
https://www.ncbi.nlm.nih.gov/pubmed/34473647
http://dx.doi.org/10.1172/jci.insight.150004

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