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Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease

Behçet’s disease (BD) is a chronic refractory multisystem autoinflammatory disease, characterized by typical clinical features of non-specific vasculitis, oral and genital ulcers, uveitis, as well as skin lesions. The exact etiopathogenesis of BD remains unknown, existing studies have indicated that...

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Autores principales: Ma, Xiaomin, Wang, Xin, Zheng, Guangbing, Tan, Guiqin, Zhou, Fangyu, Wei, Wenwen, Tian, Dan, Yu, Hongsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525702/
https://www.ncbi.nlm.nih.gov/pubmed/34676209
http://dx.doi.org/10.3389/fcell.2021.719235
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author Ma, Xiaomin
Wang, Xin
Zheng, Guangbing
Tan, Guiqin
Zhou, Fangyu
Wei, Wenwen
Tian, Dan
Yu, Hongsong
author_facet Ma, Xiaomin
Wang, Xin
Zheng, Guangbing
Tan, Guiqin
Zhou, Fangyu
Wei, Wenwen
Tian, Dan
Yu, Hongsong
author_sort Ma, Xiaomin
collection PubMed
description Behçet’s disease (BD) is a chronic refractory multisystem autoinflammatory disease, characterized by typical clinical features of non-specific vasculitis, oral and genital ulcers, uveitis, as well as skin lesions. The exact etiopathogenesis of BD remains unknown, existing studies have indicated that genetics and environmental factors contribute to the increased development of BD. Recently, several studies have shown that external environmental factors can affect the process of epigenetic modification, and abnormalities of epigenetic factors have been confirmed to be involved in the occurrence of BD. At the same time, abnormalities of gut microbiota (GM) in the body, have also been confirmed to participate in the pathogenesis of BD by regulating the balance of Th17/Tregs. This article reviews the pathogenesis of BD and summarizes numerous clinical studies, focusing on the mechanism of GM and epigenetic factors impacting on BD, and providing new ideas for further elucidating the pathogenesis of BD.
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spelling pubmed-85257022021-10-20 Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease Ma, Xiaomin Wang, Xin Zheng, Guangbing Tan, Guiqin Zhou, Fangyu Wei, Wenwen Tian, Dan Yu, Hongsong Front Cell Dev Biol Cell and Developmental Biology Behçet’s disease (BD) is a chronic refractory multisystem autoinflammatory disease, characterized by typical clinical features of non-specific vasculitis, oral and genital ulcers, uveitis, as well as skin lesions. The exact etiopathogenesis of BD remains unknown, existing studies have indicated that genetics and environmental factors contribute to the increased development of BD. Recently, several studies have shown that external environmental factors can affect the process of epigenetic modification, and abnormalities of epigenetic factors have been confirmed to be involved in the occurrence of BD. At the same time, abnormalities of gut microbiota (GM) in the body, have also been confirmed to participate in the pathogenesis of BD by regulating the balance of Th17/Tregs. This article reviews the pathogenesis of BD and summarizes numerous clinical studies, focusing on the mechanism of GM and epigenetic factors impacting on BD, and providing new ideas for further elucidating the pathogenesis of BD. Frontiers Media S.A. 2021-10-05 /pmc/articles/PMC8525702/ /pubmed/34676209 http://dx.doi.org/10.3389/fcell.2021.719235 Text en Copyright © 2021 Ma, Wang, Zheng, Tan, Zhou, Wei, Tian and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ma, Xiaomin
Wang, Xin
Zheng, Guangbing
Tan, Guiqin
Zhou, Fangyu
Wei, Wenwen
Tian, Dan
Yu, Hongsong
Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease
title Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease
title_full Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease
title_fullStr Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease
title_full_unstemmed Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease
title_short Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease
title_sort critical role of gut microbiota and epigenetic factors in the pathogenesis of behçet’s disease
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525702/
https://www.ncbi.nlm.nih.gov/pubmed/34676209
http://dx.doi.org/10.3389/fcell.2021.719235
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