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Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment

Longstanding social and economic inequities elevate health risks and vulnerabilities for Black, Indigenous and People of Color (BIPOC) communities. Engagement of BIPOC communities in infectious disease research is a critical component in efforts to increase vaccine confidence, acceptability, and upt...

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Autores principales: Andrasik, Michele P., Broder, Gail B., Wallace, Stephaun E., Chaturvedi, Richa, Michael, Nelson L., Bock, Sally, Beyrer, Chris, Oseso, Linda, Aina, Jasmin, Lucas, Jonathan, Wilson, David R., Kublin, James G., Mensah, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525736/
https://www.ncbi.nlm.nih.gov/pubmed/34665829
http://dx.doi.org/10.1371/journal.pone.0258858
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author Andrasik, Michele P.
Broder, Gail B.
Wallace, Stephaun E.
Chaturvedi, Richa
Michael, Nelson L.
Bock, Sally
Beyrer, Chris
Oseso, Linda
Aina, Jasmin
Lucas, Jonathan
Wilson, David R.
Kublin, James G.
Mensah, George A.
author_facet Andrasik, Michele P.
Broder, Gail B.
Wallace, Stephaun E.
Chaturvedi, Richa
Michael, Nelson L.
Bock, Sally
Beyrer, Chris
Oseso, Linda
Aina, Jasmin
Lucas, Jonathan
Wilson, David R.
Kublin, James G.
Mensah, George A.
author_sort Andrasik, Michele P.
collection PubMed
description Longstanding social and economic inequities elevate health risks and vulnerabilities for Black, Indigenous and People of Color (BIPOC) communities. Engagement of BIPOC communities in infectious disease research is a critical component in efforts to increase vaccine confidence, acceptability, and uptake of future approved products. Recent data highlight the relative absence of BIPOC communities in vaccine clinical trials. Intentional and effective community engagement methods are needed to improve BIPOC inclusion. We describe the methods utilized for the successful enrollment of BIPOC participants in the U.S. Government (USG)-funded COVID-19 Prevention Network (CoVPN)-sponsored vaccine efficacy trials and analyze the demographic and enrollment data across the efficacy trials to inform future efforts to ensure inclusive participation. Across the four USG-funded COVID-19 vaccine clinical trials for which data are available, 47% of participants enrolled at CoVPN sites in the US were BIPOC. White enrollment outpaced enrollment of BIPOC participants throughout the accrual period, requiring the implementation of strategies to increase diverse and inclusive enrollment. Trials opening later benefitted considerably from strengthened community engagement efforts, and greater and more diverse volunteer registry records. Despite robust fiscal resources and a longstanding collaborative and collective effort, enrollment of White persons outpaced that of BIPOC communities. With appropriate resources, commitment and community engagement expertise, the equitable enrollment of BIPOC individuals can be achieved. To ensure this goal, intentional efforts are needed, including an emphasis on diversity of enrollment in clinical trials, establishment of enrollment goals, ongoing robust community engagement, conducting population-specific trials, and research to inform best practices.
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spelling pubmed-85257362021-10-20 Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment Andrasik, Michele P. Broder, Gail B. Wallace, Stephaun E. Chaturvedi, Richa Michael, Nelson L. Bock, Sally Beyrer, Chris Oseso, Linda Aina, Jasmin Lucas, Jonathan Wilson, David R. Kublin, James G. Mensah, George A. PLoS One Research Article Longstanding social and economic inequities elevate health risks and vulnerabilities for Black, Indigenous and People of Color (BIPOC) communities. Engagement of BIPOC communities in infectious disease research is a critical component in efforts to increase vaccine confidence, acceptability, and uptake of future approved products. Recent data highlight the relative absence of BIPOC communities in vaccine clinical trials. Intentional and effective community engagement methods are needed to improve BIPOC inclusion. We describe the methods utilized for the successful enrollment of BIPOC participants in the U.S. Government (USG)-funded COVID-19 Prevention Network (CoVPN)-sponsored vaccine efficacy trials and analyze the demographic and enrollment data across the efficacy trials to inform future efforts to ensure inclusive participation. Across the four USG-funded COVID-19 vaccine clinical trials for which data are available, 47% of participants enrolled at CoVPN sites in the US were BIPOC. White enrollment outpaced enrollment of BIPOC participants throughout the accrual period, requiring the implementation of strategies to increase diverse and inclusive enrollment. Trials opening later benefitted considerably from strengthened community engagement efforts, and greater and more diverse volunteer registry records. Despite robust fiscal resources and a longstanding collaborative and collective effort, enrollment of White persons outpaced that of BIPOC communities. With appropriate resources, commitment and community engagement expertise, the equitable enrollment of BIPOC individuals can be achieved. To ensure this goal, intentional efforts are needed, including an emphasis on diversity of enrollment in clinical trials, establishment of enrollment goals, ongoing robust community engagement, conducting population-specific trials, and research to inform best practices. Public Library of Science 2021-10-19 /pmc/articles/PMC8525736/ /pubmed/34665829 http://dx.doi.org/10.1371/journal.pone.0258858 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Andrasik, Michele P.
Broder, Gail B.
Wallace, Stephaun E.
Chaturvedi, Richa
Michael, Nelson L.
Bock, Sally
Beyrer, Chris
Oseso, Linda
Aina, Jasmin
Lucas, Jonathan
Wilson, David R.
Kublin, James G.
Mensah, George A.
Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment
title Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment
title_full Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment
title_fullStr Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment
title_full_unstemmed Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment
title_short Increasing Black, Indigenous and People of Color participation in clinical trials through community engagement and recruitment goal establishment
title_sort increasing black, indigenous and people of color participation in clinical trials through community engagement and recruitment goal establishment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525736/
https://www.ncbi.nlm.nih.gov/pubmed/34665829
http://dx.doi.org/10.1371/journal.pone.0258858
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