Regulation and Role of αE Integrin and Gut Homing Integrins in Migration and Retention of Intestinal Lymphocytes during Inflammatory Bowel Disease

Targeting interactions between α4β7 integrin and endothelial adhesion molecule MAdCAM-1 to inhibit lymphocyte migration to the gastrointestinal tract is an effective therapy in inflammatory bowel disease (IBD). Following lymphocyte entry into the mucosa, a subset of these cells expresses αEβ7 integr...

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Detalles Bibliográficos
Autores principales: Keir, Mary E., Fuh, Franklin, Ichikawa, Ryan, Acres, Meghan, Hackney, Jason A., Hulme, Gillian, Carey, Christopher D., Palmer, Jeremy, Jones, Claire J., Long, Anna K., Jiang, Jenny, Klabunde, Sha, Mansfield, John C., Looney, Cary M., Faubion, William A., Filby, Andrew, Kirby, John A., McBride, Jacqueline, Lamb, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2021
Materias:
Clinical and Human Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525869/
https://www.ncbi.nlm.nih.gov/pubmed/34561227
http://dx.doi.org/10.4049/jimmunol.2100220

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