Cargando…

Bariatric Surgery Induces a Differential Effect on Plasma Aldosterone in Comparison to Dietary Advice Alone

BACKGROUND AND OBJECTIVES: The pathophysiological mechanisms linking weight loss to blood pressure (BP) reduction are not completely understood. The objective of this study was to compare the effect of weight loss after Roux-en-Y gastric bypass (RYGB) on BP, renin-angiotensin-aldosterone system (RAA...

Descripción completa

Detalles Bibliográficos
Autores principales: Berney, Maxime, Vakilzadeh, Nima, Maillard, Marc, Faouzi, Mohamed, Grouzmann, Eric, Bonny, Olivier, Favre, Lucie, Wuerzner, Grégoire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525894/
https://www.ncbi.nlm.nih.gov/pubmed/34675881
http://dx.doi.org/10.3389/fendo.2021.745045
_version_ 1784585775356051456
author Berney, Maxime
Vakilzadeh, Nima
Maillard, Marc
Faouzi, Mohamed
Grouzmann, Eric
Bonny, Olivier
Favre, Lucie
Wuerzner, Grégoire
author_facet Berney, Maxime
Vakilzadeh, Nima
Maillard, Marc
Faouzi, Mohamed
Grouzmann, Eric
Bonny, Olivier
Favre, Lucie
Wuerzner, Grégoire
author_sort Berney, Maxime
collection PubMed
description BACKGROUND AND OBJECTIVES: The pathophysiological mechanisms linking weight loss to blood pressure (BP) reduction are not completely understood. The objective of this study was to compare the effect of weight loss after Roux-en-Y gastric bypass (RYGB) on BP, renin-angiotensin-aldosterone system (RAAS), and urinary electrolytes excretion to those of dietary advice. METHODS: This was a case-control prospective study including obese patients referred for RYGB (cases) and obese receiving diet advice only (controls). Ambulatory BP, plasma renin activity (PRA), plasma aldosterone concentration (PAC), and urinary electrolytes were measured before (M0) and after intervention (M3: 3 months and M12: 12 months). RESULTS: Twenty-five patients were included in the RYGB group and twelve patients in the control group. After 12 months, weight loss (-42 ± 11.5 vs -12.3 ± 6.3 kg in the control group, p=0.001) and decrease in PAC were more pronounced in the RYGB group (-34 ± 76 vs +14 ± 45 pg/ml in the control group, p=0.002). There was no difference in PRA between both groups (-0.08 ± 1.68 vs 0.01 ± 0.37 ng/ml/h, p=0.31). Sodium excretion was more marked in the RYGB group after 3 months only (-89 ± 14.9 vs -9.9 ± 27.9 mmol/day, p=0.009). The decrease in SBP was similar between both groups (-6.9 ± 9.9 vs -7.1 ± 11.9 mmHg in the control group, p=0.96). CONCLUSIONS: Bariatric-induced weight loss induces a progressive decrease in PAC independently of PRA and sodium excretion. Whether this decrease in PAC affects target organ damage in the long term remains to be determined. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT02218112.
format Online
Article
Text
id pubmed-8525894
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85258942021-10-20 Bariatric Surgery Induces a Differential Effect on Plasma Aldosterone in Comparison to Dietary Advice Alone Berney, Maxime Vakilzadeh, Nima Maillard, Marc Faouzi, Mohamed Grouzmann, Eric Bonny, Olivier Favre, Lucie Wuerzner, Grégoire Front Endocrinol (Lausanne) Endocrinology BACKGROUND AND OBJECTIVES: The pathophysiological mechanisms linking weight loss to blood pressure (BP) reduction are not completely understood. The objective of this study was to compare the effect of weight loss after Roux-en-Y gastric bypass (RYGB) on BP, renin-angiotensin-aldosterone system (RAAS), and urinary electrolytes excretion to those of dietary advice. METHODS: This was a case-control prospective study including obese patients referred for RYGB (cases) and obese receiving diet advice only (controls). Ambulatory BP, plasma renin activity (PRA), plasma aldosterone concentration (PAC), and urinary electrolytes were measured before (M0) and after intervention (M3: 3 months and M12: 12 months). RESULTS: Twenty-five patients were included in the RYGB group and twelve patients in the control group. After 12 months, weight loss (-42 ± 11.5 vs -12.3 ± 6.3 kg in the control group, p=0.001) and decrease in PAC were more pronounced in the RYGB group (-34 ± 76 vs +14 ± 45 pg/ml in the control group, p=0.002). There was no difference in PRA between both groups (-0.08 ± 1.68 vs 0.01 ± 0.37 ng/ml/h, p=0.31). Sodium excretion was more marked in the RYGB group after 3 months only (-89 ± 14.9 vs -9.9 ± 27.9 mmol/day, p=0.009). The decrease in SBP was similar between both groups (-6.9 ± 9.9 vs -7.1 ± 11.9 mmHg in the control group, p=0.96). CONCLUSIONS: Bariatric-induced weight loss induces a progressive decrease in PAC independently of PRA and sodium excretion. Whether this decrease in PAC affects target organ damage in the long term remains to be determined. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT02218112. Frontiers Media S.A. 2021-10-05 /pmc/articles/PMC8525894/ /pubmed/34675881 http://dx.doi.org/10.3389/fendo.2021.745045 Text en Copyright © 2021 Berney, Vakilzadeh, Maillard, Faouzi, Grouzmann, Bonny, Favre and Wuerzner https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Berney, Maxime
Vakilzadeh, Nima
Maillard, Marc
Faouzi, Mohamed
Grouzmann, Eric
Bonny, Olivier
Favre, Lucie
Wuerzner, Grégoire
Bariatric Surgery Induces a Differential Effect on Plasma Aldosterone in Comparison to Dietary Advice Alone
title Bariatric Surgery Induces a Differential Effect on Plasma Aldosterone in Comparison to Dietary Advice Alone
title_full Bariatric Surgery Induces a Differential Effect on Plasma Aldosterone in Comparison to Dietary Advice Alone
title_fullStr Bariatric Surgery Induces a Differential Effect on Plasma Aldosterone in Comparison to Dietary Advice Alone
title_full_unstemmed Bariatric Surgery Induces a Differential Effect on Plasma Aldosterone in Comparison to Dietary Advice Alone
title_short Bariatric Surgery Induces a Differential Effect on Plasma Aldosterone in Comparison to Dietary Advice Alone
title_sort bariatric surgery induces a differential effect on plasma aldosterone in comparison to dietary advice alone
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525894/
https://www.ncbi.nlm.nih.gov/pubmed/34675881
http://dx.doi.org/10.3389/fendo.2021.745045
work_keys_str_mv AT berneymaxime bariatricsurgeryinducesadifferentialeffectonplasmaaldosteroneincomparisontodietaryadvicealone
AT vakilzadehnima bariatricsurgeryinducesadifferentialeffectonplasmaaldosteroneincomparisontodietaryadvicealone
AT maillardmarc bariatricsurgeryinducesadifferentialeffectonplasmaaldosteroneincomparisontodietaryadvicealone
AT faouzimohamed bariatricsurgeryinducesadifferentialeffectonplasmaaldosteroneincomparisontodietaryadvicealone
AT grouzmanneric bariatricsurgeryinducesadifferentialeffectonplasmaaldosteroneincomparisontodietaryadvicealone
AT bonnyolivier bariatricsurgeryinducesadifferentialeffectonplasmaaldosteroneincomparisontodietaryadvicealone
AT favrelucie bariatricsurgeryinducesadifferentialeffectonplasmaaldosteroneincomparisontodietaryadvicealone
AT wuerznergregoire bariatricsurgeryinducesadifferentialeffectonplasmaaldosteroneincomparisontodietaryadvicealone