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Current approaches for the exploration of antimicrobial activities of nanoparticles

Infectious diseases of bacterial and viral origins contribute to substantial mortality worldwide. Collaborative efforts have been underway between academia and the industry to develop technologies for a more effective treatment for such diseases. Due to their utility in various industrial applicatio...

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Autores principales: Rosli, Nur Ameera, Teow, Yeit Haan, Mahmoudi, Ebrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525934/
https://www.ncbi.nlm.nih.gov/pubmed/34675754
http://dx.doi.org/10.1080/14686996.2021.1978801
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author Rosli, Nur Ameera
Teow, Yeit Haan
Mahmoudi, Ebrahim
author_facet Rosli, Nur Ameera
Teow, Yeit Haan
Mahmoudi, Ebrahim
author_sort Rosli, Nur Ameera
collection PubMed
description Infectious diseases of bacterial and viral origins contribute to substantial mortality worldwide. Collaborative efforts have been underway between academia and the industry to develop technologies for a more effective treatment for such diseases. Due to their utility in various industrial applications, nanoparticles (NPs) offer promising potential as antimicrobial agents against bacterial and viral infections. NPs have been established to possess potent antimicrobial activities against various types of pathogens due to their unique characteristics and cell-damaging ability through several mechanisms. The recently accepted antimicrobial mechanisms possessed by NPs include metal ion release, oxidative stress induction, and non-oxidative mechanisms. Another merit of NPs lies in the low likelihood of the development of microbial tolerance towards NPs, given the multiple simultaneous mechanisms of action against the pathogens targeting numerous gene mutations in these pathogens. Moreover, NPs provide a fascinating opportunity to curb microbial growth before infections: this outstanding feature has led to their utilization as active antimicrobial agents in different industrial applications, e.g. the coating of medical devices, incorporation in food packaging, promoting wound healing and encapsulation with other potential materials for wastewater treatment. This review discusses the progress and achievements in the antimicrobial applications of NPs, factors contributing to their actions, mechanisms underlying their efficiency, and risks of their applications, including the antimicrobial action of metal nanoclusters (NCs). The review concludes with a discussion of the restrictions on present studies and future prospects of nanotechnology-based NPs development.
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spelling pubmed-85259342021-10-20 Current approaches for the exploration of antimicrobial activities of nanoparticles Rosli, Nur Ameera Teow, Yeit Haan Mahmoudi, Ebrahim Sci Technol Adv Mater Bio-Inspired and Biomedical Materials Infectious diseases of bacterial and viral origins contribute to substantial mortality worldwide. Collaborative efforts have been underway between academia and the industry to develop technologies for a more effective treatment for such diseases. Due to their utility in various industrial applications, nanoparticles (NPs) offer promising potential as antimicrobial agents against bacterial and viral infections. NPs have been established to possess potent antimicrobial activities against various types of pathogens due to their unique characteristics and cell-damaging ability through several mechanisms. The recently accepted antimicrobial mechanisms possessed by NPs include metal ion release, oxidative stress induction, and non-oxidative mechanisms. Another merit of NPs lies in the low likelihood of the development of microbial tolerance towards NPs, given the multiple simultaneous mechanisms of action against the pathogens targeting numerous gene mutations in these pathogens. Moreover, NPs provide a fascinating opportunity to curb microbial growth before infections: this outstanding feature has led to their utilization as active antimicrobial agents in different industrial applications, e.g. the coating of medical devices, incorporation in food packaging, promoting wound healing and encapsulation with other potential materials for wastewater treatment. This review discusses the progress and achievements in the antimicrobial applications of NPs, factors contributing to their actions, mechanisms underlying their efficiency, and risks of their applications, including the antimicrobial action of metal nanoclusters (NCs). The review concludes with a discussion of the restrictions on present studies and future prospects of nanotechnology-based NPs development. Taylor & Francis 2021-10-15 /pmc/articles/PMC8525934/ /pubmed/34675754 http://dx.doi.org/10.1080/14686996.2021.1978801 Text en © 2021 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Bio-Inspired and Biomedical Materials
Rosli, Nur Ameera
Teow, Yeit Haan
Mahmoudi, Ebrahim
Current approaches for the exploration of antimicrobial activities of nanoparticles
title Current approaches for the exploration of antimicrobial activities of nanoparticles
title_full Current approaches for the exploration of antimicrobial activities of nanoparticles
title_fullStr Current approaches for the exploration of antimicrobial activities of nanoparticles
title_full_unstemmed Current approaches for the exploration of antimicrobial activities of nanoparticles
title_short Current approaches for the exploration of antimicrobial activities of nanoparticles
title_sort current approaches for the exploration of antimicrobial activities of nanoparticles
topic Bio-Inspired and Biomedical Materials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525934/
https://www.ncbi.nlm.nih.gov/pubmed/34675754
http://dx.doi.org/10.1080/14686996.2021.1978801
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