Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway

The innate immune restriction factor SAMHD1 can inhibit diverse viruses in myeloid cells. Mechanistically, SAMHD1 inhibits lentiviral replication including HIV-1 by depleting the nucleotide pool to interfere with their reverse transcription. Equine infectious anemia virus (EIAV) is an ancient lentiv...

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Detalles Bibliográficos
Autores principales: Ren, Huiling, Yin, Xin, Su, Chao, Guo, Miaomiao, Wang, Xue-Feng, Na, Lei, Lin, Yuezhi, Wang, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525956/
https://www.ncbi.nlm.nih.gov/pubmed/33172327
http://dx.doi.org/10.1080/15548627.2020.1846301

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