PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1)

Liver dysfunction is an outstanding dose-limiting toxicity of gefitinib, an EGFR (epidermal growth factor receptor)-tyrosine kinase inhibitor (TKI), in the treatment of EGFR mutation-positive non-small cell lung cancer (NSCLC). We aimed to elucidate the mechanisms underlying gefitinib-induced hepato...

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Detalles Bibliográficos
Autores principales: Luo, Peihua, Yan, Hao, Du, Jiangxia, Chen, Xueqin, Shao, Jinjin, Zhang, Ying, Xu, Zhifei, Jin, Ying, Lin, Nengming, Yang, Bo, He, Qiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper - Translational
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526032/
https://www.ncbi.nlm.nih.gov/pubmed/33315519
http://dx.doi.org/10.1080/15548627.2020.1851492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526032/
https://www.ncbi.nlm.nih.gov/pubmed/33315519
http://dx.doi.org/10.1080/15548627.2020.1851492

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