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Neuropsychological evidence of multi-domain network hubs in the human thalamus
Hubs in the human brain support behaviors that arise from brain network interactions. Previous studies have identified hub regions in the human thalamus that are connected with multiple functional networks. However, the behavioral significance of thalamic hubs has yet to be established. Our framewor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526062/ https://www.ncbi.nlm.nih.gov/pubmed/34622776 http://dx.doi.org/10.7554/eLife.69480 |
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author | Hwang, Kai Shine, James M Bruss, Joel Tranel, Daniel Boes, Aaron |
author_facet | Hwang, Kai Shine, James M Bruss, Joel Tranel, Daniel Boes, Aaron |
author_sort | Hwang, Kai |
collection | PubMed |
description | Hubs in the human brain support behaviors that arise from brain network interactions. Previous studies have identified hub regions in the human thalamus that are connected with multiple functional networks. However, the behavioral significance of thalamic hubs has yet to be established. Our framework predicts that thalamic subregions with strong hub properties are broadly involved in functions across multiple cognitive domains. To test this prediction, we studied human patients with focal thalamic lesions in conjunction with network analyses of the human thalamocortical functional connectome. In support of our prediction, lesions to thalamic subregions with stronger hub properties were associated with widespread deficits in executive, language, and memory functions, whereas lesions to thalamic subregions with weaker hub properties were associated with more limited deficits. These results highlight how a large-scale network model can broaden our understanding of thalamic function for human cognition. |
format | Online Article Text |
id | pubmed-8526062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-85260622021-10-21 Neuropsychological evidence of multi-domain network hubs in the human thalamus Hwang, Kai Shine, James M Bruss, Joel Tranel, Daniel Boes, Aaron eLife Neuroscience Hubs in the human brain support behaviors that arise from brain network interactions. Previous studies have identified hub regions in the human thalamus that are connected with multiple functional networks. However, the behavioral significance of thalamic hubs has yet to be established. Our framework predicts that thalamic subregions with strong hub properties are broadly involved in functions across multiple cognitive domains. To test this prediction, we studied human patients with focal thalamic lesions in conjunction with network analyses of the human thalamocortical functional connectome. In support of our prediction, lesions to thalamic subregions with stronger hub properties were associated with widespread deficits in executive, language, and memory functions, whereas lesions to thalamic subregions with weaker hub properties were associated with more limited deficits. These results highlight how a large-scale network model can broaden our understanding of thalamic function for human cognition. eLife Sciences Publications, Ltd 2021-10-08 /pmc/articles/PMC8526062/ /pubmed/34622776 http://dx.doi.org/10.7554/eLife.69480 Text en © 2021, Hwang et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Hwang, Kai Shine, James M Bruss, Joel Tranel, Daniel Boes, Aaron Neuropsychological evidence of multi-domain network hubs in the human thalamus |
title | Neuropsychological evidence of multi-domain network hubs in the human thalamus |
title_full | Neuropsychological evidence of multi-domain network hubs in the human thalamus |
title_fullStr | Neuropsychological evidence of multi-domain network hubs in the human thalamus |
title_full_unstemmed | Neuropsychological evidence of multi-domain network hubs in the human thalamus |
title_short | Neuropsychological evidence of multi-domain network hubs in the human thalamus |
title_sort | neuropsychological evidence of multi-domain network hubs in the human thalamus |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526062/ https://www.ncbi.nlm.nih.gov/pubmed/34622776 http://dx.doi.org/10.7554/eLife.69480 |
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