Cargando…

BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization

BACKGROUND: Brain-derived neurotrophic factor (BDNF) influences brain plasticity and feeding behaviour, and it has been linked to anorexia nervosa in numerous studies. Findings in mostly adult patients point to reduced serum BDNF levels in the acute stage of anorexia nervosa and rising levels with w...

Descripción completa

Detalles Bibliográficos
Autores principales: Borsdorf, Britta, Dahmen, Brigitte, Buehren, Katharina, Dempfle, Astrid, Egberts, Karin, Ehrlich, Stefan, Fleischhaker, Christian, Konrad, Kerstin, Schwarte, Reinhild, Timmesfeld, Nina, Wewetzer, Christoph, Biemann, Ronald, Scharke, Wolfgang, Herpertz-Dahlmann, Beate, Seitz, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: CMA Joule Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526129/
https://www.ncbi.nlm.nih.gov/pubmed/34654737
http://dx.doi.org/10.1503/jpn.210049
_version_ 1784585815459889152
author Borsdorf, Britta
Dahmen, Brigitte
Buehren, Katharina
Dempfle, Astrid
Egberts, Karin
Ehrlich, Stefan
Fleischhaker, Christian
Konrad, Kerstin
Schwarte, Reinhild
Timmesfeld, Nina
Wewetzer, Christoph
Biemann, Ronald
Scharke, Wolfgang
Herpertz-Dahlmann, Beate
Seitz, Jochen
author_facet Borsdorf, Britta
Dahmen, Brigitte
Buehren, Katharina
Dempfle, Astrid
Egberts, Karin
Ehrlich, Stefan
Fleischhaker, Christian
Konrad, Kerstin
Schwarte, Reinhild
Timmesfeld, Nina
Wewetzer, Christoph
Biemann, Ronald
Scharke, Wolfgang
Herpertz-Dahlmann, Beate
Seitz, Jochen
author_sort Borsdorf, Britta
collection PubMed
description BACKGROUND: Brain-derived neurotrophic factor (BDNF) influences brain plasticity and feeding behaviour, and it has been linked to anorexia nervosa in numerous studies. Findings in mostly adult patients point to reduced serum BDNF levels in the acute stage of anorexia nervosa and rising levels with weight recovery. However, it is unclear whether this increase leads to normalization or supranormal levels, a difference that is potentially important for the etiology of anorexia nervosa and relapse. METHODS: We measured serum BDNF at admission (n = 149), discharge (n = 130), 1-year follow-up (n = 116) and 2.5-year follow-up (n = 76) in adolescent female patients with anorexia nervosa hospitalized for the first time, and in healthy controls (n = 79). We analyzed associations with body mass index, eating disorder psychopathology and comorbidities. RESULTS: Serum BDNF was only nominally lower at admission in patients with anorexia nervosa compared to healthy controls, but it increased continuously and reached supranormal levels at 2.5-year follow-up. BDNF was inversely associated with eating disorder psychopathology at discharge and positively associated with previous weight gain at 1-year follow-up. LIMITATIONS: We compensated for attrition and batch effects using statistical measures. CONCLUSION: In this largest longitudinal study to date, we found only nonsignificant reductions in BDNF in the acute stage of anorexia nervosa, possibly because of a shorter illness duration in adolescent patients. Supranormal levels of BDNF at 2.5-year follow-up could represent a pre-existing trait or a consequence of the illness. Because of the anorexigenic effect of BDNF, it might play an important predisposing role for relapse and should be explored further in studies that test causality.
format Online
Article
Text
id pubmed-8526129
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher CMA Joule Inc.
record_format MEDLINE/PubMed
spelling pubmed-85261292021-10-22 BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization Borsdorf, Britta Dahmen, Brigitte Buehren, Katharina Dempfle, Astrid Egberts, Karin Ehrlich, Stefan Fleischhaker, Christian Konrad, Kerstin Schwarte, Reinhild Timmesfeld, Nina Wewetzer, Christoph Biemann, Ronald Scharke, Wolfgang Herpertz-Dahlmann, Beate Seitz, Jochen J Psychiatry Neurosci Research Paper BACKGROUND: Brain-derived neurotrophic factor (BDNF) influences brain plasticity and feeding behaviour, and it has been linked to anorexia nervosa in numerous studies. Findings in mostly adult patients point to reduced serum BDNF levels in the acute stage of anorexia nervosa and rising levels with weight recovery. However, it is unclear whether this increase leads to normalization or supranormal levels, a difference that is potentially important for the etiology of anorexia nervosa and relapse. METHODS: We measured serum BDNF at admission (n = 149), discharge (n = 130), 1-year follow-up (n = 116) and 2.5-year follow-up (n = 76) in adolescent female patients with anorexia nervosa hospitalized for the first time, and in healthy controls (n = 79). We analyzed associations with body mass index, eating disorder psychopathology and comorbidities. RESULTS: Serum BDNF was only nominally lower at admission in patients with anorexia nervosa compared to healthy controls, but it increased continuously and reached supranormal levels at 2.5-year follow-up. BDNF was inversely associated with eating disorder psychopathology at discharge and positively associated with previous weight gain at 1-year follow-up. LIMITATIONS: We compensated for attrition and batch effects using statistical measures. CONCLUSION: In this largest longitudinal study to date, we found only nonsignificant reductions in BDNF in the acute stage of anorexia nervosa, possibly because of a shorter illness duration in adolescent patients. Supranormal levels of BDNF at 2.5-year follow-up could represent a pre-existing trait or a consequence of the illness. Because of the anorexigenic effect of BDNF, it might play an important predisposing role for relapse and should be explored further in studies that test causality. CMA Joule Inc. 2021-10-15 /pmc/articles/PMC8526129/ /pubmed/34654737 http://dx.doi.org/10.1503/jpn.210049 Text en © 2021 CMA Joule Inc. or its licensors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Research Paper
Borsdorf, Britta
Dahmen, Brigitte
Buehren, Katharina
Dempfle, Astrid
Egberts, Karin
Ehrlich, Stefan
Fleischhaker, Christian
Konrad, Kerstin
Schwarte, Reinhild
Timmesfeld, Nina
Wewetzer, Christoph
Biemann, Ronald
Scharke, Wolfgang
Herpertz-Dahlmann, Beate
Seitz, Jochen
BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization
title BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization
title_full BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization
title_fullStr BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization
title_full_unstemmed BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization
title_short BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization
title_sort bdnf levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526129/
https://www.ncbi.nlm.nih.gov/pubmed/34654737
http://dx.doi.org/10.1503/jpn.210049
work_keys_str_mv AT borsdorfbritta bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT dahmenbrigitte bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT buehrenkatharina bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT dempfleastrid bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT egbertskarin bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT ehrlichstefan bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT fleischhakerchristian bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT konradkerstin bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT schwartereinhild bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT timmesfeldnina bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT wewetzerchristoph bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT biemannronald bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT scharkewolfgang bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT herpertzdahlmannbeate bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization
AT seitzjochen bdnflevelsinadolescentpatientswithanorexianervosaincreasecontinuouslytosupranormallevels25yearsafterfirsthospitalization