Cargando…

Cannabis use and resting state functional connectivity in adolescent bipolar disorder

BACKGROUND: Adolescents with bipolar disorder have high rates of cannabis use, and cannabis use is associated with increased symptom severity and treatment resistance in bipolar disorder. Studies have identified anomalous resting-state functional connectivity among reward networks in bipolar disorde...

Descripción completa

Detalles Bibliográficos
Autores principales: Sultan, Alysha A., Hird, Megan A., Dimick, Mikaela K., MacIntosh, Bradley J., Goldstein, Benjamin I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: CMA Joule Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526158/
https://www.ncbi.nlm.nih.gov/pubmed/34625488
http://dx.doi.org/10.1503/jpn.200228
_version_ 1784585822052286464
author Sultan, Alysha A.
Hird, Megan A.
Dimick, Mikaela K.
MacIntosh, Bradley J.
Goldstein, Benjamin I.
author_facet Sultan, Alysha A.
Hird, Megan A.
Dimick, Mikaela K.
MacIntosh, Bradley J.
Goldstein, Benjamin I.
author_sort Sultan, Alysha A.
collection PubMed
description BACKGROUND: Adolescents with bipolar disorder have high rates of cannabis use, and cannabis use is associated with increased symptom severity and treatment resistance in bipolar disorder. Studies have identified anomalous resting-state functional connectivity among reward networks in bipolar disorder and cannabis use independently, but have yet to examine their convergence. METHODS: Participants included 134 adolescents, aged 13 to 20 years: 40 with bipolar disorder and lifetime cannabis use, 31 with bipolar disorder and no history of cannabis use, and 63 healthy controls without lifetime cannabis use. We used a seed-to-voxel analysis to assess the restingstate functional connectivity of the amygdala, the nucleus accumbens and the orbitofrontal cortex, regions implicated in bipolar disorder and cannabis use. We used a generalized linear model to explore bivariate correlations for each seed, controlling for age and sex. RESULTS: We found 3 significant clusters. Resting-state functional connectivity between the left nucleus accumbens seed and the left superior parietal lobe was negative in adolescents with bipolar disorder and no history of cannabis use, and positive in healthy controls. Resting-state functional connectivity between the right orbitofrontal cortex seed and the right lateral occipital cortex was positive in adolescents with bipolar disorder and lifetime cannabis use, and negative in healthy controls and adolescents with bipolar disorder and no history of cannabis use. Resting-state functional connectivity between the right orbitofrontal cortex seed and right occipital pole was positive in adolescents with bipolar disorder and lifetime cannabis use, and negative in adolescents with bipolar disorder and no history of cannabis use. LIMITATIONS: The study did not include a cannabis-using control group. CONCLUSION: This study provides preliminary evidence of cannabis-related differences in functional reward circuits in adolescents with bipolar disorder. Further studies are necessary to evaluate whether the present findings reflect consequences of or predisposition to cannabis use.
format Online
Article
Text
id pubmed-8526158
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher CMA Joule Inc.
record_format MEDLINE/PubMed
spelling pubmed-85261582021-10-22 Cannabis use and resting state functional connectivity in adolescent bipolar disorder Sultan, Alysha A. Hird, Megan A. Dimick, Mikaela K. MacIntosh, Bradley J. Goldstein, Benjamin I. J Psychiatry Neurosci Research Paper BACKGROUND: Adolescents with bipolar disorder have high rates of cannabis use, and cannabis use is associated with increased symptom severity and treatment resistance in bipolar disorder. Studies have identified anomalous resting-state functional connectivity among reward networks in bipolar disorder and cannabis use independently, but have yet to examine their convergence. METHODS: Participants included 134 adolescents, aged 13 to 20 years: 40 with bipolar disorder and lifetime cannabis use, 31 with bipolar disorder and no history of cannabis use, and 63 healthy controls without lifetime cannabis use. We used a seed-to-voxel analysis to assess the restingstate functional connectivity of the amygdala, the nucleus accumbens and the orbitofrontal cortex, regions implicated in bipolar disorder and cannabis use. We used a generalized linear model to explore bivariate correlations for each seed, controlling for age and sex. RESULTS: We found 3 significant clusters. Resting-state functional connectivity between the left nucleus accumbens seed and the left superior parietal lobe was negative in adolescents with bipolar disorder and no history of cannabis use, and positive in healthy controls. Resting-state functional connectivity between the right orbitofrontal cortex seed and the right lateral occipital cortex was positive in adolescents with bipolar disorder and lifetime cannabis use, and negative in healthy controls and adolescents with bipolar disorder and no history of cannabis use. Resting-state functional connectivity between the right orbitofrontal cortex seed and right occipital pole was positive in adolescents with bipolar disorder and lifetime cannabis use, and negative in adolescents with bipolar disorder and no history of cannabis use. LIMITATIONS: The study did not include a cannabis-using control group. CONCLUSION: This study provides preliminary evidence of cannabis-related differences in functional reward circuits in adolescents with bipolar disorder. Further studies are necessary to evaluate whether the present findings reflect consequences of or predisposition to cannabis use. CMA Joule Inc. 2021-10-08 /pmc/articles/PMC8526158/ /pubmed/34625488 http://dx.doi.org/10.1503/jpn.200228 Text en © 2021 CMA Joule Inc. or its licensors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Research Paper
Sultan, Alysha A.
Hird, Megan A.
Dimick, Mikaela K.
MacIntosh, Bradley J.
Goldstein, Benjamin I.
Cannabis use and resting state functional connectivity in adolescent bipolar disorder
title Cannabis use and resting state functional connectivity in adolescent bipolar disorder
title_full Cannabis use and resting state functional connectivity in adolescent bipolar disorder
title_fullStr Cannabis use and resting state functional connectivity in adolescent bipolar disorder
title_full_unstemmed Cannabis use and resting state functional connectivity in adolescent bipolar disorder
title_short Cannabis use and resting state functional connectivity in adolescent bipolar disorder
title_sort cannabis use and resting state functional connectivity in adolescent bipolar disorder
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526158/
https://www.ncbi.nlm.nih.gov/pubmed/34625488
http://dx.doi.org/10.1503/jpn.200228
work_keys_str_mv AT sultanalyshaa cannabisuseandrestingstatefunctionalconnectivityinadolescentbipolardisorder
AT hirdmegana cannabisuseandrestingstatefunctionalconnectivityinadolescentbipolardisorder
AT dimickmikaelak cannabisuseandrestingstatefunctionalconnectivityinadolescentbipolardisorder
AT macintoshbradleyj cannabisuseandrestingstatefunctionalconnectivityinadolescentbipolardisorder
AT goldsteinbenjamini cannabisuseandrestingstatefunctionalconnectivityinadolescentbipolardisorder