The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development

Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatment’s effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the...

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Detalles Bibliográficos
Autores principales: Kuchur, O. A., Kuzmina, D. O., Dukhinova, M. S., Shtil, A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526179/
https://www.ncbi.nlm.nih.gov/pubmed/34707898
http://dx.doi.org/10.32607/actanaturae.11247
Descripción
Sumario:Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatment’s effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the development of radioresistance. This review analyzes the p53-dependent and p53-independent mechanisms involved in overcoming the resistance of tumor cells to radiation exposure

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