The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development

Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatment’s effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the...

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Detalles Bibliográficos
Autores principales: Kuchur, O. A., Kuzmina, D. O., Dukhinova, M. S., Shtil, A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526179/
https://www.ncbi.nlm.nih.gov/pubmed/34707898
http://dx.doi.org/10.32607/actanaturae.11247
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author Kuchur, O. A.
Kuzmina, D. O.
Dukhinova, M. S.
Shtil, A. A.
author_facet Kuchur, O. A.
Kuzmina, D. O.
Dukhinova, M. S.
Shtil, A. A.
author_sort Kuchur, O. A.
collection PubMed
description Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatment’s effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the development of radioresistance. This review analyzes the p53-dependent and p53-independent mechanisms involved in overcoming the resistance of tumor cells to radiation exposure
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spelling pubmed-85261792021-10-26 The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development Kuchur, O. A. Kuzmina, D. O. Dukhinova, M. S. Shtil, A. A. Acta Naturae Research Article Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatment’s effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the development of radioresistance. This review analyzes the p53-dependent and p53-independent mechanisms involved in overcoming the resistance of tumor cells to radiation exposure A.I. Gordeyev 2021 /pmc/articles/PMC8526179/ /pubmed/34707898 http://dx.doi.org/10.32607/actanaturae.11247 Text en Copyright ® 2021 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kuchur, O. A.
Kuzmina, D. O.
Dukhinova, M. S.
Shtil, A. A.
The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development
title The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development
title_full The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development
title_fullStr The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development
title_full_unstemmed The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development
title_short The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development
title_sort p53 protein family in the response of tumor cells to ionizing radiation: problem development
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526179/
https://www.ncbi.nlm.nih.gov/pubmed/34707898
http://dx.doi.org/10.32607/actanaturae.11247
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