Inactivating Gene Expression with Antisense Modified Oligonucleotides

Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomple...

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Detalles Bibliográficos
Autores principales: Altman, Sidney, Angele-Martinez, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526185/
https://www.ncbi.nlm.nih.gov/pubmed/34707901
http://dx.doi.org/10.32607/actanaturae.11522
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author Altman, Sidney
Angele-Martinez, Carlos
author_facet Altman, Sidney
Angele-Martinez, Carlos
author_sort Altman, Sidney
collection PubMed
description Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides.
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spelling pubmed-85261852021-10-26 Inactivating Gene Expression with Antisense Modified Oligonucleotides Altman, Sidney Angele-Martinez, Carlos Acta Naturae Research Article Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides. A.I. Gordeyev 2021 /pmc/articles/PMC8526185/ /pubmed/34707901 http://dx.doi.org/10.32607/actanaturae.11522 Text en Copyright ® 2021 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Altman, Sidney
Angele-Martinez, Carlos
Inactivating Gene Expression with Antisense Modified Oligonucleotides
title Inactivating Gene Expression with Antisense Modified Oligonucleotides
title_full Inactivating Gene Expression with Antisense Modified Oligonucleotides
title_fullStr Inactivating Gene Expression with Antisense Modified Oligonucleotides
title_full_unstemmed Inactivating Gene Expression with Antisense Modified Oligonucleotides
title_short Inactivating Gene Expression with Antisense Modified Oligonucleotides
title_sort inactivating gene expression with antisense modified oligonucleotides
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526185/
https://www.ncbi.nlm.nih.gov/pubmed/34707901
http://dx.doi.org/10.32607/actanaturae.11522
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