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Inhibition of the Immunoproteasome Subunit LMP7 Ameliorates Cerebral White Matter Demyelination Possibly via TGFβ/Smad Signaling

OBJECTIVES: Chronic cerebral hypoperfusion induces white matter ischemic injury and cognitive impairment, whereas the mechanism remains unclear. Immunoproteasomes have been implicated in the pathogenesis of acute ischemia stroke and multiple sclerosis. However, the expression and role of immunoprote...

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Detalles Bibliográficos
Autores principales:	Chen, Xingyong, Yao, Nannan, Lin, Zejing, Wang, Yinzhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526201/ https://www.ncbi.nlm.nih.gov/pubmed/34675988 http://dx.doi.org/10.1155/2021/6426225

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