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An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors
Several studies have suggested that coatomer protein complex subunit beta 2 (COPB2) may act as an oncogene in various cancer types. However, no systematic pan-cancer analysis has been performed to date. Therefore, the present study analyzed the potential oncogenic role of COPB2 using TCGA (The Cance...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526247/ https://www.ncbi.nlm.nih.gov/pubmed/34676262 http://dx.doi.org/10.1155/2021/7405322 |
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author | Wu, Biao Wu, Yumeng Guo, Xianlin Yue, Yanping Li, Yuanyuan He, Xiao Chen, Yuanbin Zhao, Wenjing Liu, Jibin Wu, Xuming Shen, Aiguo Zhang, Suqing |
author_facet | Wu, Biao Wu, Yumeng Guo, Xianlin Yue, Yanping Li, Yuanyuan He, Xiao Chen, Yuanbin Zhao, Wenjing Liu, Jibin Wu, Xuming Shen, Aiguo Zhang, Suqing |
author_sort | Wu, Biao |
collection | PubMed |
description | Several studies have suggested that coatomer protein complex subunit beta 2 (COPB2) may act as an oncogene in various cancer types. However, no systematic pan-cancer analysis has been performed to date. Therefore, the present study analyzed the potential oncogenic role of COPB2 using TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) datasets. The majority of the cancer types overexpressed the COPB2 protein, and its expression significantly correlated with tumor prognosis. In certain tumors, such as those found in breast and ovarian tissues, phosphorylated S859 exhibited high expression. It was found that mutations of the COPB2 protein in kidney and endometrial cancers exhibited a significant impact on patient prognosis. It is interesting to note that COPB2 expression correlated with the number of cancer-associated fibroblasts in certain tumors, such as cervical and endocervical cancers and colon adenocarcinomas. In addition, COPB2 was involved in the transport of substances and correlated with chemotherapy sensitivity. This is considered the first pan-tumor study, which provided a relatively comprehensive understanding of the mechanism by which COPB2 promotes cancer growth. |
format | Online Article Text |
id | pubmed-8526247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-85262472021-10-20 An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors Wu, Biao Wu, Yumeng Guo, Xianlin Yue, Yanping Li, Yuanyuan He, Xiao Chen, Yuanbin Zhao, Wenjing Liu, Jibin Wu, Xuming Shen, Aiguo Zhang, Suqing Biomed Res Int Research Article Several studies have suggested that coatomer protein complex subunit beta 2 (COPB2) may act as an oncogene in various cancer types. However, no systematic pan-cancer analysis has been performed to date. Therefore, the present study analyzed the potential oncogenic role of COPB2 using TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) datasets. The majority of the cancer types overexpressed the COPB2 protein, and its expression significantly correlated with tumor prognosis. In certain tumors, such as those found in breast and ovarian tissues, phosphorylated S859 exhibited high expression. It was found that mutations of the COPB2 protein in kidney and endometrial cancers exhibited a significant impact on patient prognosis. It is interesting to note that COPB2 expression correlated with the number of cancer-associated fibroblasts in certain tumors, such as cervical and endocervical cancers and colon adenocarcinomas. In addition, COPB2 was involved in the transport of substances and correlated with chemotherapy sensitivity. This is considered the first pan-tumor study, which provided a relatively comprehensive understanding of the mechanism by which COPB2 promotes cancer growth. Hindawi 2021-10-12 /pmc/articles/PMC8526247/ /pubmed/34676262 http://dx.doi.org/10.1155/2021/7405322 Text en Copyright © 2021 Biao Wu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wu, Biao Wu, Yumeng Guo, Xianlin Yue, Yanping Li, Yuanyuan He, Xiao Chen, Yuanbin Zhao, Wenjing Liu, Jibin Wu, Xuming Shen, Aiguo Zhang, Suqing An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors |
title | An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors |
title_full | An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors |
title_fullStr | An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors |
title_full_unstemmed | An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors |
title_short | An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors |
title_sort | integrative pan-cancer analysis of the oncogenic role of copb2 in human tumors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526247/ https://www.ncbi.nlm.nih.gov/pubmed/34676262 http://dx.doi.org/10.1155/2021/7405322 |
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