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Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan
INTRODUCTION: The ability to predict which patients with a history of coronavirus disease (COVID-19) will exhibit a high antibody titer is necessary for more efficient screening of potential convalescent plasma donors. We aimed to identify factors associated with a high immunoglobulin G (IgG) titer...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526427/ https://www.ncbi.nlm.nih.gov/pubmed/34756573 http://dx.doi.org/10.1016/j.jiac.2021.10.012 |
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author | Suzuki, Tetsuya Asai, Yusuke Ide, Satoshi Fukuda, Saori Tanaka, Akihito Shimanishi, Yumiko Takahashi, Kozue Terada, Mari Sato, Lubna Sato, Mitsuhiro Inada, Makoto Yamada, Gen Miyazato, Yusuke Akiyama, Yutaro Nomoto, Hidetoshi Nakamoto, Takato Nakamura, Keiji Togano, Tomiteru Morioka, Shinichiro Kinoshita-Iwamoto, Noriko Saito, Sho Kutsuna, Satoshi Ohmagari, Norio |
author_facet | Suzuki, Tetsuya Asai, Yusuke Ide, Satoshi Fukuda, Saori Tanaka, Akihito Shimanishi, Yumiko Takahashi, Kozue Terada, Mari Sato, Lubna Sato, Mitsuhiro Inada, Makoto Yamada, Gen Miyazato, Yusuke Akiyama, Yutaro Nomoto, Hidetoshi Nakamoto, Takato Nakamura, Keiji Togano, Tomiteru Morioka, Shinichiro Kinoshita-Iwamoto, Noriko Saito, Sho Kutsuna, Satoshi Ohmagari, Norio |
author_sort | Suzuki, Tetsuya |
collection | PubMed |
description | INTRODUCTION: The ability to predict which patients with a history of coronavirus disease (COVID-19) will exhibit a high antibody titer is necessary for more efficient screening of potential convalescent plasma donors. We aimed to identify factors associated with a high immunoglobulin G (IgG) titer in Japanese convalescent plasma donors after COVID-19. METHODS: This cross-sectional study included volunteers undergoing screening for convalescent plasma donation after COVID-19. Serum anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S-protein IgG antibodies were measured using a high-sensitivity chemiluminescence enzyme immunoassay. RESULTS: IgG antibodies were measured in 581 patients, 534 of whom had full information of selected independent variables. Multiple linear regression analysis revealed that increasing age (1.037 [1,025, 1.048]), days from symptom onset to sampling (0.997 [0.995, 0.998]), fever (1.664 [1.226, 2.259]), systemic corticosteroid use during SARS-CoV-2 infection (2.382 [1.576, 3.601]), and blood type AB (1.478 [1.032, 2.117]) predict antibody titer. CONCLUSION: Older participants, those who experienced fever during infection, those treated with systemic corticosteroids during infection, those from whom samples were obtained earlier after symptom onset, and those with blood type AB are the best candidates for convalescent plasma donation. Therefore, these factors should be incorporated into the screening criteria for convalescent plasma donation after SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-8526427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85264272021-10-20 Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan Suzuki, Tetsuya Asai, Yusuke Ide, Satoshi Fukuda, Saori Tanaka, Akihito Shimanishi, Yumiko Takahashi, Kozue Terada, Mari Sato, Lubna Sato, Mitsuhiro Inada, Makoto Yamada, Gen Miyazato, Yusuke Akiyama, Yutaro Nomoto, Hidetoshi Nakamoto, Takato Nakamura, Keiji Togano, Tomiteru Morioka, Shinichiro Kinoshita-Iwamoto, Noriko Saito, Sho Kutsuna, Satoshi Ohmagari, Norio J Infect Chemother Original Article INTRODUCTION: The ability to predict which patients with a history of coronavirus disease (COVID-19) will exhibit a high antibody titer is necessary for more efficient screening of potential convalescent plasma donors. We aimed to identify factors associated with a high immunoglobulin G (IgG) titer in Japanese convalescent plasma donors after COVID-19. METHODS: This cross-sectional study included volunteers undergoing screening for convalescent plasma donation after COVID-19. Serum anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S-protein IgG antibodies were measured using a high-sensitivity chemiluminescence enzyme immunoassay. RESULTS: IgG antibodies were measured in 581 patients, 534 of whom had full information of selected independent variables. Multiple linear regression analysis revealed that increasing age (1.037 [1,025, 1.048]), days from symptom onset to sampling (0.997 [0.995, 0.998]), fever (1.664 [1.226, 2.259]), systemic corticosteroid use during SARS-CoV-2 infection (2.382 [1.576, 3.601]), and blood type AB (1.478 [1.032, 2.117]) predict antibody titer. CONCLUSION: Older participants, those who experienced fever during infection, those treated with systemic corticosteroids during infection, those from whom samples were obtained earlier after symptom onset, and those with blood type AB are the best candidates for convalescent plasma donation. Therefore, these factors should be incorporated into the screening criteria for convalescent plasma donation after SARS-CoV-2 infection. Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2022-02 2021-10-20 /pmc/articles/PMC8526427/ /pubmed/34756573 http://dx.doi.org/10.1016/j.jiac.2021.10.012 Text en © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Suzuki, Tetsuya Asai, Yusuke Ide, Satoshi Fukuda, Saori Tanaka, Akihito Shimanishi, Yumiko Takahashi, Kozue Terada, Mari Sato, Lubna Sato, Mitsuhiro Inada, Makoto Yamada, Gen Miyazato, Yusuke Akiyama, Yutaro Nomoto, Hidetoshi Nakamoto, Takato Nakamura, Keiji Togano, Tomiteru Morioka, Shinichiro Kinoshita-Iwamoto, Noriko Saito, Sho Kutsuna, Satoshi Ohmagari, Norio Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan |
title | Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan |
title_full | Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan |
title_fullStr | Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan |
title_full_unstemmed | Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan |
title_short | Factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: A single-center cross-sectional study in Japan |
title_sort | factors associated with high antibody titer following coronavirus disease among 581 convalescent plasma donors: a single-center cross-sectional study in japan |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526427/ https://www.ncbi.nlm.nih.gov/pubmed/34756573 http://dx.doi.org/10.1016/j.jiac.2021.10.012 |
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