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Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks

Viral diseases are emerging as global threats. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that causes coronavirus disease (COVID-19), has severe global impacts. Safety, dosage, and potency of vaccines recently approved for emergency use against SARS-CoV-2 need further evaluation....

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Autores principales: Tayeb, Hossam H., Felimban, Raed, Almaghrabi, Sarah, Hasaballah, Nojod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526445/
https://www.ncbi.nlm.nih.gov/pubmed/34692429
http://dx.doi.org/10.1016/j.colcom.2021.100533
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author Tayeb, Hossam H.
Felimban, Raed
Almaghrabi, Sarah
Hasaballah, Nojod
author_facet Tayeb, Hossam H.
Felimban, Raed
Almaghrabi, Sarah
Hasaballah, Nojod
author_sort Tayeb, Hossam H.
collection PubMed
description Viral diseases are emerging as global threats. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that causes coronavirus disease (COVID-19), has severe global impacts. Safety, dosage, and potency of vaccines recently approved for emergency use against SARS-CoV-2 need further evaluation. There is still no effective treatment against COVID-19; therefore, safe, and effective vaccines or therapeutics against SARS-CoV-2 are urgently needed. Oil-in-water nanoemulsions (O/W NEs) are emerging as sophisticated, protective, and therapeutic platforms. Encapsulation capacity, which offers better drug pharmacokinetics, coupled with the tunable surfaces present NEs as promising tools for pharmaceutical applications. The challenges facing drug discovery, and the advancements of NEs in drug delivery demonstrate the potential of NEs against evolving diseases, like COVID-19. Here we summarize current COVID-19 knowledge and discuss the composition, stability, preparation, characterization, and biological fate of O/W NEs. We also provide insights into NE structural-functional properties that may contribute to therapeutic or preventative solutions against COVID-19.
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spelling pubmed-85264452021-10-20 Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks Tayeb, Hossam H. Felimban, Raed Almaghrabi, Sarah Hasaballah, Nojod Colloid Interface Sci Commun Article Viral diseases are emerging as global threats. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that causes coronavirus disease (COVID-19), has severe global impacts. Safety, dosage, and potency of vaccines recently approved for emergency use against SARS-CoV-2 need further evaluation. There is still no effective treatment against COVID-19; therefore, safe, and effective vaccines or therapeutics against SARS-CoV-2 are urgently needed. Oil-in-water nanoemulsions (O/W NEs) are emerging as sophisticated, protective, and therapeutic platforms. Encapsulation capacity, which offers better drug pharmacokinetics, coupled with the tunable surfaces present NEs as promising tools for pharmaceutical applications. The challenges facing drug discovery, and the advancements of NEs in drug delivery demonstrate the potential of NEs against evolving diseases, like COVID-19. Here we summarize current COVID-19 knowledge and discuss the composition, stability, preparation, characterization, and biological fate of O/W NEs. We also provide insights into NE structural-functional properties that may contribute to therapeutic or preventative solutions against COVID-19. The Authors. Published by Elsevier B.V. 2021-11 2021-10-20 /pmc/articles/PMC8526445/ /pubmed/34692429 http://dx.doi.org/10.1016/j.colcom.2021.100533 Text en © 2021 The Authors. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tayeb, Hossam H.
Felimban, Raed
Almaghrabi, Sarah
Hasaballah, Nojod
Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks
title Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks
title_full Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks
title_fullStr Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks
title_full_unstemmed Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks
title_short Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks
title_sort nanoemulsions: formulation, characterization, biological fate, and potential role against covid-19 and other viral outbreaks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526445/
https://www.ncbi.nlm.nih.gov/pubmed/34692429
http://dx.doi.org/10.1016/j.colcom.2021.100533
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