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Upregulation of CD22 by Chidamide promotes CAR T cells functionality

Treatment failure or relapse due to tumor escape caused by reduction in target antigen expression has become a challenge in the field of CART therapy. Target antigen density is closely related to the effectiveness of CART therapy, and reduced or lost target antigen expression limits the efficacy of...

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Detalles Bibliográficos
Autores principales: Yang, Xin, Yu, Qiuxia, Xu, Hao, Zhou, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526578/
https://www.ncbi.nlm.nih.gov/pubmed/34667217
http://dx.doi.org/10.1038/s41598-021-00227-4