Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling

Numb, a stem cell fate determinant, acts as a tumor suppressor and is closely related to a wide variety of malignancies. Intrahepatic cholangiocarcinoma (iCCA) originates from hepatic progenitors (HPCs); however, the role of Numb in HPC malignant transformation and iCCA development is still unclear....

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Detalles Bibliográficos
Autores principales: Shu, Yuke, Xu, Qing, Xu, Yahong, Tao, Qing, Shao, Mingyang, Cao, Xiaoyue, Chen, Yuwei, Wu, Zhenru, Chen, Menglin, Zhou, Yongjie, Zhou, Ping, Shi, Yujun, Bu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526591/
https://www.ncbi.nlm.nih.gov/pubmed/34667161
http://dx.doi.org/10.1038/s41419-021-04263-w

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