Phosphoglycerate kinase 1 silencing by a novel microRNA microRNA-4523 protects human osteoblasts from dexamethasone through activation of Nrf2 signaling cascade

Nuclear-factor-E2-related factor 2 (Nrf2) cascade activation can ameliorate dexamethasone (DEX)-induced oxidative injury and death in human osteoblasts. Phosphoglycerate kinase 1 (PGK1) depletion is shown to efficiently activate Nrf2 signaling by inducing methylglyoxal modification of Kelch-like ECH...

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Detalles Bibliográficos
Autores principales: Liang, Jin-qian, Zhou, Zhen-tao, Bo, Lin, Tan, Hai-ning, Hu, Jian-hua, Tan, Ming-sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526604/
https://www.ncbi.nlm.nih.gov/pubmed/34667156
http://dx.doi.org/10.1038/s41419-021-04250-1

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