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Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA

Y-family DNA polymerase κ (Pol κ) can replicate damaged DNA templates to rescue stalled replication forks. Access of Pol κ to DNA damage sites is facilitated by its interaction with the processivity clamp PCNA and is regulated by PCNA mono-ubiquitylation. Here, we present cryo-EM reconstructions of...

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Detalles Bibliográficos
Autores principales:	Lancey, Claudia, Tehseen, Muhammad, Bakshi, Souvika, Percival, Matthew, Takahashi, Masateru, Sobhy, Mohamed A., Raducanu, Vlad S., Blair, Kerry, Muskett, Frederick W., Ragan, Timothy J., Crehuet, Ramon, Hamdan, Samir M., De Biasio, Alfredo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526622/ https://www.ncbi.nlm.nih.gov/pubmed/34667155 http://dx.doi.org/10.1038/s41467-021-26251-6

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