PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC

The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a regulatory hub for transcription and RNA processing. Here, we identify PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks onto Pol II CTD through its SPOC domain. We character...

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Detalles Bibliográficos
Autores principales: Appel, Lisa-Marie, Franke, Vedran, Bruno, Melania, Grishkovskaya, Irina, Kasiliauskaite, Aiste, Kaufmann, Tanja, Schoeberl, Ursula E., Puchinger, Martin G., Kostrhon, Sebastian, Ebenwaldner, Carmen, Sebesta, Marek, Beltzung, Etienne, Mechtler, Karl, Lin, Gen, Vlasova, Anna, Leeb, Martin, Pavri, Rushad, Stark, Alexander, Akalin, Altuna, Stefl, Richard, Bernecky, Carrie, Djinovic-Carugo, Kristina, Slade, Dea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526623/
https://www.ncbi.nlm.nih.gov/pubmed/34667177
http://dx.doi.org/10.1038/s41467-021-26360-2

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