suPAR, a Circulating Kidney Disease Factor

Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a...

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Detalles Bibliográficos
Autores principales: Wei, Changli, Spear, Ryan, Hahm, Eunsil, Reiser, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526732/
https://www.ncbi.nlm.nih.gov/pubmed/34692736
http://dx.doi.org/10.3389/fmed.2021.745838
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author Wei, Changli
Spear, Ryan
Hahm, Eunsil
Reiser, Jochen
author_facet Wei, Changli
Spear, Ryan
Hahm, Eunsil
Reiser, Jochen
author_sort Wei, Changli
collection PubMed
description Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms.
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spelling pubmed-85267322021-10-21 suPAR, a Circulating Kidney Disease Factor Wei, Changli Spear, Ryan Hahm, Eunsil Reiser, Jochen Front Med (Lausanne) Medicine Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms. Frontiers Media S.A. 2021-10-06 /pmc/articles/PMC8526732/ /pubmed/34692736 http://dx.doi.org/10.3389/fmed.2021.745838 Text en Copyright © 2021 Wei, Spear, Hahm and Reiser. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Wei, Changli
Spear, Ryan
Hahm, Eunsil
Reiser, Jochen
suPAR, a Circulating Kidney Disease Factor
title suPAR, a Circulating Kidney Disease Factor
title_full suPAR, a Circulating Kidney Disease Factor
title_fullStr suPAR, a Circulating Kidney Disease Factor
title_full_unstemmed suPAR, a Circulating Kidney Disease Factor
title_short suPAR, a Circulating Kidney Disease Factor
title_sort supar, a circulating kidney disease factor
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526732/
https://www.ncbi.nlm.nih.gov/pubmed/34692736
http://dx.doi.org/10.3389/fmed.2021.745838
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