Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19

This analysis presents a systematic evaluation of the extent of therapeutic opportunities that can be obtained from drug repurposing by connecting drug targets with disease genes. When using FDA-approved indications as a reference level we found that drug repurposing can offer an average of an 11-fo...

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Detalles Bibliográficos
Autores principales: Rivero-García, Inés, Castresana-Aguirre, Miguel, Guglielmo, Luca, Guala, Dimitri, Sonnhammer, Erik L. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526804/
https://www.ncbi.nlm.nih.gov/pubmed/34667255
http://dx.doi.org/10.1038/s41598-021-99721-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526804/
https://www.ncbi.nlm.nih.gov/pubmed/34667255
http://dx.doi.org/10.1038/s41598-021-99721-y

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