mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity

Postmortem studies have revealed increased density of excitatory synapses in the brains of individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR-dependent synaptic pruning. ASD is also characterized by atypical macroscale functional connectivity as measured with rest...

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Detalles Bibliográficos
Autores principales: Pagani, Marco, Barsotti, Noemi, Bertero, Alice, Trakoshis, Stavros, Ulysse, Laura, Locarno, Andrea, Miseviciute, Ieva, De Felice, Alessia, Canella, Carola, Supekar, Kaustubh, Galbusera, Alberto, Menon, Vinod, Tonini, Raffaella, Deco, Gustavo, Lombardo, Michael V., Pasqualetti, Massimo, Gozzi, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526836/
https://www.ncbi.nlm.nih.gov/pubmed/34667149
http://dx.doi.org/10.1038/s41467-021-26131-z

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