Cargando…

HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis

Statins are an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). Growing evidence indicates that statins may have an anti-inflammatory effect. Whether genetically proxied HMGCR inhibition can reduce the risk of ankylosing spondylitis is unknown. We constructed an HMGCR genetic sc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhong, Zhenyu, Feng, Xiaojie, Su, Guannan, Du, Liping, Liao, Weiting, Liu, Shengyun, Li, Fuzhen, Zuo, Xianbo, Yang, Peizeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526849/ https://www.ncbi.nlm.nih.gov/pubmed/34692687 http://dx.doi.org/10.3389/fcell.2021.731072

Ejemplares similares

Hsa_circ_0000652 Aggravates Inflammation by Activation of Macrophages and Enhancement of OX40/OX40L Interaction in Ankylosing Spondylitis
por: Song, Minkai, et al.
Publicado: (2021)

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis
por: Liao, Hsien-Tzung, et al.
Publicado: (2022)

Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with Ubiad1 deficiency
por: Jo, Youngah, et al.
Publicado: (2020)

The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila
por: Alsehli, Ahmed M., et al.
Publicado: (2022)

The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
por: Friesen, Jon A, et al.
Publicado: (2004)

Selection of HMG-coenzyme A reductase inhibitors using multiattribute scoring tool
por: Ramli, Azuana, et al.
Publicado: (2012)

Comparative Efficacy and Safety of Advanced Intravitreal Therapeutic Agents for Noninfectious Uveitis: A Systematic Review and Network Meta-Analysis
por: Liao, Weiting, et al.
Publicado: (2022)

Identification of Urine Metabolic Biomarkers for Vogt-Koyanagi-Harada Disease
por: Chang, Rui, et al.
Publicado: (2021)

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
por: Menzies, Sam A, et al.
Publicado: (2018)

Changes in the Gut Microbiome Contribute to the Development of Behcet’s Disease via Adjuvant Effects
por: Wang, Qingfeng, et al.
Publicado: (2021)

Detection of Fuchs’ Uveitis Syndrome From Slit-Lamp Images Using Deep Convolutional Neural Networks in a Chinese Population
por: Zhang, Wanyun, et al.
Publicado: (2021)

Case-Control Study and Meta-Analysis Show a Weak Association between ANTXR2 Polymorphisms and Ankylosing Spondylitis in Chinese Han
por: Hu, Jiayue, et al.
Publicado: (2018)

High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms
por: Pan, Su, et al.
Publicado: (2021)

Impaired Barrier Function and Immunity in the Colon of Aldo-Keto Reductase 1B8 Deficient Mice
por: Wang, Xin, et al.
Publicado: (2021)

Distinct Functions of Acyl/Alkyl Dihydroxyacetonephosphate Reductase in Peroxisomes and Endoplasmic Reticulum
por: Honsho, Masanori, et al.
Publicado: (2020)

A Single-Cell Transcriptome Atlas of the Human Retinal Pigment Epithelium
por: Xu, Zongren, et al.
Publicado: (2021)

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
por: Swerdlow, Daniel I, et al.
Publicado: (2015)

A Functional Variant of PTPN22 Confers Risk for Vogt-Koyanagi-Harada Syndrome but Not for Ankylosing Spondylitis
por: Zhang, Qi, et al.
Publicado: (2014)

Ankylosing spondylitis
Publicado: (1980)

Ankylosing spondylitis
por: Edavalath, Mukesh
Publicado: (2010)

Ankylosing Spondylitis
por: Whitfield, A. G. W.
Publicado: (1976)

Ankylosing Spondylitis
por: Ebrahimiadib, Nazanin, et al.
Publicado: (2021)

Predictive Modeling of HMG-CoA Reductase Inhibitory Activity and Design of New HMG-CoA Reductase Inhibitors
por: Samizo, Shigeyoshi, et al.
Publicado: (2023)

Aldose Reductase B1 in Pig Seminal Plasma: Identification, Localization in Reproductive Tissues, and Relationship With Quality and Sperm Preservation
por: Mateo-Otero, Yentel, et al.
Publicado: (2021)

Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary
por: Song, Yanlong, et al.
Publicado: (2022)

Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis
por: Zhang, Xu, et al.
Publicado: (2016)

Schedule-Dependent Synergy Between the Histone Deacetylase Inhibitor Belinostat and the Dihydrofolate Reductase Inhibitor Pralatrexate in T-and B-cell Lymphoma Cells in vitro
por: Peters, Godefridus J., et al.
Publicado: (2020)

Pyrroline-5-Carboxylate Reductase 1 Directs the Cartilage Protective and Regenerative Potential of Murphy Roths Large Mouse Mesenchymal Stem Cells
por: Tejedor, Gautier, et al.
Publicado: (2021)

Isodeoxyelephantopin Inactivates Thioredoxin Reductase 1 and Activates ROS-Mediated JNK Signaling Pathway to Exacerbate Cisplatin Effectiveness in Human Colon Cancer Cells
por: Hong, Lin, et al.
Publicado: (2020)

Identification of Gingivitis-Related Genes Across Human Tissues Based on the Summary Mendelian Randomization
por: Zhang, Jiahui, et al.
Publicado: (2021)

Cytokines and regulatory T cells in ankylosing spondylitis
por: Liao, Hsien-Tzung, et al.
Publicado: (2023)

T lymphocyte subset imbalances in patients contribute to ankylosing spondylitis
por: WANG, CHENGGONG, et al.
Publicado: (2015)

Imaging of ankylosing spondylitis
por: Østergaard, Mikkel
Publicado: (2012)

Alexithymia in ankylosing spondylitis
por: Karabıçak, Deniz, et al.
Publicado: (2021)

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?
por: Gonzalez-Jimenez, Irene, et al.
Publicado: (2021)

7-Acetoxyhorminone from Salvia multicaulis Vahl. as Promising Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase
por: Yigitkan, Serkan, et al.
Publicado: (2022)

Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (Anti-HMG CoA) Myopathy With Cardiac Involvement: Presentation, Diagnosis, and Management
por: Liu, Lisa, et al.
Publicado: (2022)

Pleiotropic effects of the HMG-CoA reductase inhibitors
por: Mihos, Christos G, et al.
Publicado: (2011)

A novel prognostic signature and immune microenvironment characteristics associated with disulfidptosis in papillary thyroid carcinoma based on single-cell RNA sequencing
por: Liao, Zhenyu, et al.
Publicado: (2023)

Cancer-Associated Fibroblasts Promote Vascular Invasion of Hepatocellular Carcinoma via Downregulating Decorin-integrin β1 Signaling
por: Zheng, Xiaobo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dlictkvg8d616t6tdk3pn6uuon