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TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma
BACKGROUND: HNSCC is a heterogeneous disease, which arises from distinct anatomic subsites, associates with various risk factors and possesses diverse molecular pathological features. Generally, HNSCC is considered as an immunosuppressive disease, characterized by abnormal tumor immune microenvironm...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526904/ https://www.ncbi.nlm.nih.gov/pubmed/34691075 http://dx.doi.org/10.3389/fimmu.2021.754818 |
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author | Long, Qian Huang, Chunyu Meng, Qi Peng, Jin Yao, Fan Du, Dingfu Wang, Xiaonan Zhu, Wancui Shi, Dingbo Xu, Xiangdong Qi, Xiang Deng, Wuguo Chen, Miao Li, Yizhuo Yang, Ankui |
author_facet | Long, Qian Huang, Chunyu Meng, Qi Peng, Jin Yao, Fan Du, Dingfu Wang, Xiaonan Zhu, Wancui Shi, Dingbo Xu, Xiangdong Qi, Xiang Deng, Wuguo Chen, Miao Li, Yizhuo Yang, Ankui |
author_sort | Long, Qian |
collection | PubMed |
description | BACKGROUND: HNSCC is a heterogeneous disease, which arises from distinct anatomic subsites, associates with various risk factors and possesses diverse molecular pathological features. Generally, HNSCC is considered as an immunosuppressive disease, characterized by abnormal tumor immune microenvironment. The TNF family plays a crucial role in the survival, proliferation, differentiation, and effector functions in both immune and non-immune cells. However, the expression patterns of TNF in HNSCC remains to be systematically analyzed. METHODS: We downloaded transcriptional profile data of HNSCC from TCGA and GEO datasets. Unsupervised clustering methods were used to identify different TNF patterns and classify patients for further analysis. PCA was conducted to construct a TNF relevant score, which we called risk score. RESULTS: In this study, we systematically evaluated the patterns of TNF family and tumor immune microenvironment characteristics of HNSCC patients by clustering the expression of 46 members of TNF family. We identified two subtypes with distinct clinical and immune characteristics in HNSCC and constructed a risk scoring system based on the expression profile of TNF family genes. CONCLUSION: Risk score serves as a reliable predictor of overall survival, clinical characteristics, and immune cell infiltration, which has the potential to be applied as a valuable biomarker for HNSCC immunotherapy. |
format | Online Article Text |
id | pubmed-8526904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85269042021-10-21 TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma Long, Qian Huang, Chunyu Meng, Qi Peng, Jin Yao, Fan Du, Dingfu Wang, Xiaonan Zhu, Wancui Shi, Dingbo Xu, Xiangdong Qi, Xiang Deng, Wuguo Chen, Miao Li, Yizhuo Yang, Ankui Front Immunol Immunology BACKGROUND: HNSCC is a heterogeneous disease, which arises from distinct anatomic subsites, associates with various risk factors and possesses diverse molecular pathological features. Generally, HNSCC is considered as an immunosuppressive disease, characterized by abnormal tumor immune microenvironment. The TNF family plays a crucial role in the survival, proliferation, differentiation, and effector functions in both immune and non-immune cells. However, the expression patterns of TNF in HNSCC remains to be systematically analyzed. METHODS: We downloaded transcriptional profile data of HNSCC from TCGA and GEO datasets. Unsupervised clustering methods were used to identify different TNF patterns and classify patients for further analysis. PCA was conducted to construct a TNF relevant score, which we called risk score. RESULTS: In this study, we systematically evaluated the patterns of TNF family and tumor immune microenvironment characteristics of HNSCC patients by clustering the expression of 46 members of TNF family. We identified two subtypes with distinct clinical and immune characteristics in HNSCC and constructed a risk scoring system based on the expression profile of TNF family genes. CONCLUSION: Risk score serves as a reliable predictor of overall survival, clinical characteristics, and immune cell infiltration, which has the potential to be applied as a valuable biomarker for HNSCC immunotherapy. Frontiers Media S.A. 2021-10-06 /pmc/articles/PMC8526904/ /pubmed/34691075 http://dx.doi.org/10.3389/fimmu.2021.754818 Text en Copyright © 2021 Long, Huang, Meng, Peng, Yao, Du, Wang, Zhu, Shi, Xu, Qi, Deng, Chen, Li and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Long, Qian Huang, Chunyu Meng, Qi Peng, Jin Yao, Fan Du, Dingfu Wang, Xiaonan Zhu, Wancui Shi, Dingbo Xu, Xiangdong Qi, Xiang Deng, Wuguo Chen, Miao Li, Yizhuo Yang, Ankui TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma |
title | TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma |
title_full | TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma |
title_fullStr | TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma |
title_full_unstemmed | TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma |
title_short | TNF Patterns and Tumor Microenvironment Characterization in Head and Neck Squamous Cell Carcinoma |
title_sort | tnf patterns and tumor microenvironment characterization in head and neck squamous cell carcinoma |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526904/ https://www.ncbi.nlm.nih.gov/pubmed/34691075 http://dx.doi.org/10.3389/fimmu.2021.754818 |
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