Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints

Several lines of evidence point towards the central role of IL-23 as a crucial inflammatory mediator in the pathogenesis of SpA—a group of inflammatory arthritic diseases whose symptoms span the skin, gastrointestinal tract and joints. While therapeutic blockade of IL-23 proved successful in the tre...

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Autores principales: Łukasik, Zuzanna, Gracey, Eric, Venken, Koen, Ritchlin, Christopher, Elewaut, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527243/
https://www.ncbi.nlm.nih.gov/pubmed/33961030
http://dx.doi.org/10.1093/rheumatology/keab385
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author Łukasik, Zuzanna
Gracey, Eric
Venken, Koen
Ritchlin, Christopher
Elewaut, Dirk
author_facet Łukasik, Zuzanna
Gracey, Eric
Venken, Koen
Ritchlin, Christopher
Elewaut, Dirk
author_sort Łukasik, Zuzanna
collection PubMed
description Several lines of evidence point towards the central role of IL-23 as a crucial inflammatory mediator in the pathogenesis of SpA—a group of inflammatory arthritic diseases whose symptoms span the skin, gastrointestinal tract and joints. While therapeutic blockade of IL-23 proved successful in the treatment of IBD, psoriatic skin disease and peripheral SpA, it failed in patients suffering from SpA with predominantly axial involvement. Here we review state-of-the-art discoveries on IL-23 signalling pathways across target tissues involved in SpA. We discuss the discrepancies in resident IL-23–responding cells and their downstream activities across skin, gut and joint that shape the unique immunological landscape of SpA.
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spelling pubmed-85272432021-10-20 Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints Łukasik, Zuzanna Gracey, Eric Venken, Koen Ritchlin, Christopher Elewaut, Dirk Rheumatology (Oxford) Supplement Papers Several lines of evidence point towards the central role of IL-23 as a crucial inflammatory mediator in the pathogenesis of SpA—a group of inflammatory arthritic diseases whose symptoms span the skin, gastrointestinal tract and joints. While therapeutic blockade of IL-23 proved successful in the treatment of IBD, psoriatic skin disease and peripheral SpA, it failed in patients suffering from SpA with predominantly axial involvement. Here we review state-of-the-art discoveries on IL-23 signalling pathways across target tissues involved in SpA. We discuss the discrepancies in resident IL-23–responding cells and their downstream activities across skin, gut and joint that shape the unique immunological landscape of SpA. Oxford University Press 2021-05-07 /pmc/articles/PMC8527243/ /pubmed/33961030 http://dx.doi.org/10.1093/rheumatology/keab385 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Supplement Papers
Łukasik, Zuzanna
Gracey, Eric
Venken, Koen
Ritchlin, Christopher
Elewaut, Dirk
Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints
title Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints
title_full Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints
title_fullStr Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints
title_full_unstemmed Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints
title_short Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints
title_sort crossing the boundaries: il-23 and its role in linking inflammation of the skin, gut and joints
topic Supplement Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527243/
https://www.ncbi.nlm.nih.gov/pubmed/33961030
http://dx.doi.org/10.1093/rheumatology/keab385
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