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Practical management of patients with hematological diseases during the COVID-19 pandemic in Japan
Polymerase chain reaction (PCR) tests cannot always detect the SARS-CoV-2 virus, possibly due to differences in sensitivity between sample types. Under these circumstances, immunochromatography may serve as an alternative method to detect anti-SARS-CoV-2 IgG antibodies that indicate a history of inf...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527309/ https://www.ncbi.nlm.nih.gov/pubmed/34669154 http://dx.doi.org/10.1007/s12185-021-03175-x |
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author | Hagihara, Masao Ohara, Shin Uchida, Tomoyuki Inoue, Morihiro |
author_facet | Hagihara, Masao Ohara, Shin Uchida, Tomoyuki Inoue, Morihiro |
author_sort | Hagihara, Masao |
collection | PubMed |
description | Polymerase chain reaction (PCR) tests cannot always detect the SARS-CoV-2 virus, possibly due to differences in sensitivity between sample types. Under these circumstances, immunochromatography may serve as an alternative method to detect anti-SARS-CoV-2 IgG antibodies that indicate a history of infection. In our analysis of patients with severe COVID-19 infection, we found that 14 of 19 serum samples were positive for IgG antibodies, whereas 6 of 10 samples from patients with asymptomatic or mild cases were negative. Two patients with immune thrombocytopenia who were treated with prednisolone experienced aggressive COVID-19-related respiratory failure and eventually died. Patients not in remission and those who received steroid-based chemotherapy had a higher risk of death, and patients with lymphoid malignancies including lymphoma and myeloma died in larger numbers than those with myeloid malignancies. A stricter cohorting strategy based on repeat PCR tests or isolation to a private room should be adopted in routine care in hematology departments to prevent viral spread to the environment. |
format | Online Article Text |
id | pubmed-8527309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-85273092021-10-20 Practical management of patients with hematological diseases during the COVID-19 pandemic in Japan Hagihara, Masao Ohara, Shin Uchida, Tomoyuki Inoue, Morihiro Int J Hematol Original Article Polymerase chain reaction (PCR) tests cannot always detect the SARS-CoV-2 virus, possibly due to differences in sensitivity between sample types. Under these circumstances, immunochromatography may serve as an alternative method to detect anti-SARS-CoV-2 IgG antibodies that indicate a history of infection. In our analysis of patients with severe COVID-19 infection, we found that 14 of 19 serum samples were positive for IgG antibodies, whereas 6 of 10 samples from patients with asymptomatic or mild cases were negative. Two patients with immune thrombocytopenia who were treated with prednisolone experienced aggressive COVID-19-related respiratory failure and eventually died. Patients not in remission and those who received steroid-based chemotherapy had a higher risk of death, and patients with lymphoid malignancies including lymphoma and myeloma died in larger numbers than those with myeloid malignancies. A stricter cohorting strategy based on repeat PCR tests or isolation to a private room should be adopted in routine care in hematology departments to prevent viral spread to the environment. Springer Singapore 2021-10-20 2021 /pmc/articles/PMC8527309/ /pubmed/34669154 http://dx.doi.org/10.1007/s12185-021-03175-x Text en © Japanese Society of Hematology 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Hagihara, Masao Ohara, Shin Uchida, Tomoyuki Inoue, Morihiro Practical management of patients with hematological diseases during the COVID-19 pandemic in Japan |
title | Practical management of patients with hematological diseases during the COVID-19 pandemic in Japan |
title_full | Practical management of patients with hematological diseases during the COVID-19 pandemic in Japan |
title_fullStr | Practical management of patients with hematological diseases during the COVID-19 pandemic in Japan |
title_full_unstemmed | Practical management of patients with hematological diseases during the COVID-19 pandemic in Japan |
title_short | Practical management of patients with hematological diseases during the COVID-19 pandemic in Japan |
title_sort | practical management of patients with hematological diseases during the covid-19 pandemic in japan |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527309/ https://www.ncbi.nlm.nih.gov/pubmed/34669154 http://dx.doi.org/10.1007/s12185-021-03175-x |
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