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Prevalence and predictors of post-liver transplantation metabolic bone diseases

INTRODUCTION: Post-liver transplantation (LTx) bone diseases have been poorly investigated. The frequency of bone diseases (osteopenia and osteoporosis) after LTx is unknown. AIM OF THE STUDY: To define prevalence and risk factors of bone disorders following LTx. MATERIAL AND METHODS: This prospecti...

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Autores principales: Elsabaawy, Maha, Afify, Sameh, El-Azab, Gasser, Gomaa, Asmaa, Omar, Nabil, Hashim, Mohamed, Elsabaawy, Dalia, Elshazly, Helmy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527345/
https://www.ncbi.nlm.nih.gov/pubmed/34712830
http://dx.doi.org/10.5114/ceh.2021.109412
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author Elsabaawy, Maha
Afify, Sameh
El-Azab, Gasser
Gomaa, Asmaa
Omar, Nabil
Hashim, Mohamed
Elsabaawy, Dalia
Elshazly, Helmy
author_facet Elsabaawy, Maha
Afify, Sameh
El-Azab, Gasser
Gomaa, Asmaa
Omar, Nabil
Hashim, Mohamed
Elsabaawy, Dalia
Elshazly, Helmy
author_sort Elsabaawy, Maha
collection PubMed
description INTRODUCTION: Post-liver transplantation (LTx) bone diseases have been poorly investigated. The frequency of bone diseases (osteopenia and osteoporosis) after LTx is unknown. AIM OF THE STUDY: To define prevalence and risk factors of bone disorders following LTx. MATERIAL AND METHODS: This prospective study was conducted on 100 consecutive adult patients who underwent living donor liver transplantation (LDLT) at the National Liver Institute (NLI) and survived longer than a year. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorption (DEXA), as well as other pre- and postoperative risk factors. RESULTS: The frequencies of osteopenia and osteoporosis were found to be 14% and 8% among post-LTx patients. Seven recipients of the osteoporotic group were males, with mean age, and body mass index (BMI) before and after LTx 49.5 ±7.4 years, 24.1 ±4.7 kg/m(2) and 22.8 ±1.5 kg/m(2), respectively. A significant association between hepatitis C virus (HCV)-related cirrhosis, liver disease severity according to Child-Turcotte-Pugh (CTP) score, and alcoholism with decreased post-LTx BMD was substantiated (p < 0.05, 0.006). Post-LTx development of diabetes mellitus (DM), weight gain, use of corticosteroids and basiliximab all significantly affected decreased post-LTx BMD (p < 0.05). However, binary regression revealed that post-LTx occurrence of DM (p = 0.012, odds ratio [OR] = 0.099), the severity of liver disease (p = 0.023, OR = 0.217), and HCV (p = 0.011, OR = 0.173) are the main independent predictors of metabolic bone disease (MBD) occurrence one year after LTx. CONCLUSIONS: Post-LTx bone disorders are not infrequent complications and should be more considered in those with HCV-related severe liver disease or developed DM after LTx.
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spelling pubmed-85273452021-10-27 Prevalence and predictors of post-liver transplantation metabolic bone diseases Elsabaawy, Maha Afify, Sameh El-Azab, Gasser Gomaa, Asmaa Omar, Nabil Hashim, Mohamed Elsabaawy, Dalia Elshazly, Helmy Clin Exp Hepatol Original Paper INTRODUCTION: Post-liver transplantation (LTx) bone diseases have been poorly investigated. The frequency of bone diseases (osteopenia and osteoporosis) after LTx is unknown. AIM OF THE STUDY: To define prevalence and risk factors of bone disorders following LTx. MATERIAL AND METHODS: This prospective study was conducted on 100 consecutive adult patients who underwent living donor liver transplantation (LDLT) at the National Liver Institute (NLI) and survived longer than a year. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorption (DEXA), as well as other pre- and postoperative risk factors. RESULTS: The frequencies of osteopenia and osteoporosis were found to be 14% and 8% among post-LTx patients. Seven recipients of the osteoporotic group were males, with mean age, and body mass index (BMI) before and after LTx 49.5 ±7.4 years, 24.1 ±4.7 kg/m(2) and 22.8 ±1.5 kg/m(2), respectively. A significant association between hepatitis C virus (HCV)-related cirrhosis, liver disease severity according to Child-Turcotte-Pugh (CTP) score, and alcoholism with decreased post-LTx BMD was substantiated (p < 0.05, 0.006). Post-LTx development of diabetes mellitus (DM), weight gain, use of corticosteroids and basiliximab all significantly affected decreased post-LTx BMD (p < 0.05). However, binary regression revealed that post-LTx occurrence of DM (p = 0.012, odds ratio [OR] = 0.099), the severity of liver disease (p = 0.023, OR = 0.217), and HCV (p = 0.011, OR = 0.173) are the main independent predictors of metabolic bone disease (MBD) occurrence one year after LTx. CONCLUSIONS: Post-LTx bone disorders are not infrequent complications and should be more considered in those with HCV-related severe liver disease or developed DM after LTx. Termedia Publishing House 2021-10-11 2021-09 /pmc/articles/PMC8527345/ /pubmed/34712830 http://dx.doi.org/10.5114/ceh.2021.109412 Text en Copyright © 2021 Clinical and Experimental Hepatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Original Paper
Elsabaawy, Maha
Afify, Sameh
El-Azab, Gasser
Gomaa, Asmaa
Omar, Nabil
Hashim, Mohamed
Elsabaawy, Dalia
Elshazly, Helmy
Prevalence and predictors of post-liver transplantation metabolic bone diseases
title Prevalence and predictors of post-liver transplantation metabolic bone diseases
title_full Prevalence and predictors of post-liver transplantation metabolic bone diseases
title_fullStr Prevalence and predictors of post-liver transplantation metabolic bone diseases
title_full_unstemmed Prevalence and predictors of post-liver transplantation metabolic bone diseases
title_short Prevalence and predictors of post-liver transplantation metabolic bone diseases
title_sort prevalence and predictors of post-liver transplantation metabolic bone diseases
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527345/
https://www.ncbi.nlm.nih.gov/pubmed/34712830
http://dx.doi.org/10.5114/ceh.2021.109412
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