Cargando…
Prevalence and predictors of post-liver transplantation metabolic bone diseases
INTRODUCTION: Post-liver transplantation (LTx) bone diseases have been poorly investigated. The frequency of bone diseases (osteopenia and osteoporosis) after LTx is unknown. AIM OF THE STUDY: To define prevalence and risk factors of bone disorders following LTx. MATERIAL AND METHODS: This prospecti...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527345/ https://www.ncbi.nlm.nih.gov/pubmed/34712830 http://dx.doi.org/10.5114/ceh.2021.109412 |
_version_ | 1784586056824258560 |
---|---|
author | Elsabaawy, Maha Afify, Sameh El-Azab, Gasser Gomaa, Asmaa Omar, Nabil Hashim, Mohamed Elsabaawy, Dalia Elshazly, Helmy |
author_facet | Elsabaawy, Maha Afify, Sameh El-Azab, Gasser Gomaa, Asmaa Omar, Nabil Hashim, Mohamed Elsabaawy, Dalia Elshazly, Helmy |
author_sort | Elsabaawy, Maha |
collection | PubMed |
description | INTRODUCTION: Post-liver transplantation (LTx) bone diseases have been poorly investigated. The frequency of bone diseases (osteopenia and osteoporosis) after LTx is unknown. AIM OF THE STUDY: To define prevalence and risk factors of bone disorders following LTx. MATERIAL AND METHODS: This prospective study was conducted on 100 consecutive adult patients who underwent living donor liver transplantation (LDLT) at the National Liver Institute (NLI) and survived longer than a year. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorption (DEXA), as well as other pre- and postoperative risk factors. RESULTS: The frequencies of osteopenia and osteoporosis were found to be 14% and 8% among post-LTx patients. Seven recipients of the osteoporotic group were males, with mean age, and body mass index (BMI) before and after LTx 49.5 ±7.4 years, 24.1 ±4.7 kg/m(2) and 22.8 ±1.5 kg/m(2), respectively. A significant association between hepatitis C virus (HCV)-related cirrhosis, liver disease severity according to Child-Turcotte-Pugh (CTP) score, and alcoholism with decreased post-LTx BMD was substantiated (p < 0.05, 0.006). Post-LTx development of diabetes mellitus (DM), weight gain, use of corticosteroids and basiliximab all significantly affected decreased post-LTx BMD (p < 0.05). However, binary regression revealed that post-LTx occurrence of DM (p = 0.012, odds ratio [OR] = 0.099), the severity of liver disease (p = 0.023, OR = 0.217), and HCV (p = 0.011, OR = 0.173) are the main independent predictors of metabolic bone disease (MBD) occurrence one year after LTx. CONCLUSIONS: Post-LTx bone disorders are not infrequent complications and should be more considered in those with HCV-related severe liver disease or developed DM after LTx. |
format | Online Article Text |
id | pubmed-8527345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-85273452021-10-27 Prevalence and predictors of post-liver transplantation metabolic bone diseases Elsabaawy, Maha Afify, Sameh El-Azab, Gasser Gomaa, Asmaa Omar, Nabil Hashim, Mohamed Elsabaawy, Dalia Elshazly, Helmy Clin Exp Hepatol Original Paper INTRODUCTION: Post-liver transplantation (LTx) bone diseases have been poorly investigated. The frequency of bone diseases (osteopenia and osteoporosis) after LTx is unknown. AIM OF THE STUDY: To define prevalence and risk factors of bone disorders following LTx. MATERIAL AND METHODS: This prospective study was conducted on 100 consecutive adult patients who underwent living donor liver transplantation (LDLT) at the National Liver Institute (NLI) and survived longer than a year. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorption (DEXA), as well as other pre- and postoperative risk factors. RESULTS: The frequencies of osteopenia and osteoporosis were found to be 14% and 8% among post-LTx patients. Seven recipients of the osteoporotic group were males, with mean age, and body mass index (BMI) before and after LTx 49.5 ±7.4 years, 24.1 ±4.7 kg/m(2) and 22.8 ±1.5 kg/m(2), respectively. A significant association between hepatitis C virus (HCV)-related cirrhosis, liver disease severity according to Child-Turcotte-Pugh (CTP) score, and alcoholism with decreased post-LTx BMD was substantiated (p < 0.05, 0.006). Post-LTx development of diabetes mellitus (DM), weight gain, use of corticosteroids and basiliximab all significantly affected decreased post-LTx BMD (p < 0.05). However, binary regression revealed that post-LTx occurrence of DM (p = 0.012, odds ratio [OR] = 0.099), the severity of liver disease (p = 0.023, OR = 0.217), and HCV (p = 0.011, OR = 0.173) are the main independent predictors of metabolic bone disease (MBD) occurrence one year after LTx. CONCLUSIONS: Post-LTx bone disorders are not infrequent complications and should be more considered in those with HCV-related severe liver disease or developed DM after LTx. Termedia Publishing House 2021-10-11 2021-09 /pmc/articles/PMC8527345/ /pubmed/34712830 http://dx.doi.org/10.5114/ceh.2021.109412 Text en Copyright © 2021 Clinical and Experimental Hepatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Original Paper Elsabaawy, Maha Afify, Sameh El-Azab, Gasser Gomaa, Asmaa Omar, Nabil Hashim, Mohamed Elsabaawy, Dalia Elshazly, Helmy Prevalence and predictors of post-liver transplantation metabolic bone diseases |
title | Prevalence and predictors of post-liver transplantation metabolic bone diseases |
title_full | Prevalence and predictors of post-liver transplantation metabolic bone diseases |
title_fullStr | Prevalence and predictors of post-liver transplantation metabolic bone diseases |
title_full_unstemmed | Prevalence and predictors of post-liver transplantation metabolic bone diseases |
title_short | Prevalence and predictors of post-liver transplantation metabolic bone diseases |
title_sort | prevalence and predictors of post-liver transplantation metabolic bone diseases |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527345/ https://www.ncbi.nlm.nih.gov/pubmed/34712830 http://dx.doi.org/10.5114/ceh.2021.109412 |
work_keys_str_mv | AT elsabaawymaha prevalenceandpredictorsofpostlivertransplantationmetabolicbonediseases AT afifysameh prevalenceandpredictorsofpostlivertransplantationmetabolicbonediseases AT elazabgasser prevalenceandpredictorsofpostlivertransplantationmetabolicbonediseases AT gomaaasmaa prevalenceandpredictorsofpostlivertransplantationmetabolicbonediseases AT omarnabil prevalenceandpredictorsofpostlivertransplantationmetabolicbonediseases AT hashimmohamed prevalenceandpredictorsofpostlivertransplantationmetabolicbonediseases AT elsabaawydalia prevalenceandpredictorsofpostlivertransplantationmetabolicbonediseases AT elshazlyhelmy prevalenceandpredictorsofpostlivertransplantationmetabolicbonediseases |