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Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions

Lower urinary tract (LUT) dysfunction is common in the older adult. Aging is associated with a number of both storage and voiding problems which are classified into syndromes with overlapping symptoms. Despite the prevalence and consequences of these syndromes, LUT disorders continue to be undertrea...

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Detalles Bibliográficos
Autores principales: Birder, Lori A., Jackson, Edwin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527459/
https://www.ncbi.nlm.nih.gov/pubmed/34676378
http://dx.doi.org/10.20900/agmr20210018
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author Birder, Lori A.
Jackson, Edwin K.
author_facet Birder, Lori A.
Jackson, Edwin K.
author_sort Birder, Lori A.
collection PubMed
description Lower urinary tract (LUT) dysfunction is common in the older adult. Aging is associated with a number of both storage and voiding problems which are classified into syndromes with overlapping symptoms. Despite the prevalence and consequences of these syndromes, LUT disorders continue to be undertreated as few therapeutic options exist. Here, we propose that dysregulated metabolism of purine nucleotides results in an accumulation of uro-damaging hypoxanthine (a source of reactive oxygen species or ROS), which provides a mechanism for defects in sensory signaling and contractility, culminating in abnormal urodynamic behavior.
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spelling pubmed-85274592021-10-20 Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions Birder, Lori A. Jackson, Edwin K. Adv Geriatr Med Res Article Lower urinary tract (LUT) dysfunction is common in the older adult. Aging is associated with a number of both storage and voiding problems which are classified into syndromes with overlapping symptoms. Despite the prevalence and consequences of these syndromes, LUT disorders continue to be undertreated as few therapeutic options exist. Here, we propose that dysregulated metabolism of purine nucleotides results in an accumulation of uro-damaging hypoxanthine (a source of reactive oxygen species or ROS), which provides a mechanism for defects in sensory signaling and contractility, culminating in abnormal urodynamic behavior. 2021-09-29 2021 /pmc/articles/PMC8527459/ /pubmed/34676378 http://dx.doi.org/10.20900/agmr20210018 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Birder, Lori A.
Jackson, Edwin K.
Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions
title Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions
title_full Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions
title_fullStr Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions
title_full_unstemmed Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions
title_short Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions
title_sort dysregulated purine metabolism contributes to age-associated lower urinary tract dysfunctions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527459/
https://www.ncbi.nlm.nih.gov/pubmed/34676378
http://dx.doi.org/10.20900/agmr20210018
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