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Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions
Lower urinary tract (LUT) dysfunction is common in the older adult. Aging is associated with a number of both storage and voiding problems which are classified into syndromes with overlapping symptoms. Despite the prevalence and consequences of these syndromes, LUT disorders continue to be undertrea...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527459/ https://www.ncbi.nlm.nih.gov/pubmed/34676378 http://dx.doi.org/10.20900/agmr20210018 |
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author | Birder, Lori A. Jackson, Edwin K. |
author_facet | Birder, Lori A. Jackson, Edwin K. |
author_sort | Birder, Lori A. |
collection | PubMed |
description | Lower urinary tract (LUT) dysfunction is common in the older adult. Aging is associated with a number of both storage and voiding problems which are classified into syndromes with overlapping symptoms. Despite the prevalence and consequences of these syndromes, LUT disorders continue to be undertreated as few therapeutic options exist. Here, we propose that dysregulated metabolism of purine nucleotides results in an accumulation of uro-damaging hypoxanthine (a source of reactive oxygen species or ROS), which provides a mechanism for defects in sensory signaling and contractility, culminating in abnormal urodynamic behavior. |
format | Online Article Text |
id | pubmed-8527459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-85274592021-10-20 Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions Birder, Lori A. Jackson, Edwin K. Adv Geriatr Med Res Article Lower urinary tract (LUT) dysfunction is common in the older adult. Aging is associated with a number of both storage and voiding problems which are classified into syndromes with overlapping symptoms. Despite the prevalence and consequences of these syndromes, LUT disorders continue to be undertreated as few therapeutic options exist. Here, we propose that dysregulated metabolism of purine nucleotides results in an accumulation of uro-damaging hypoxanthine (a source of reactive oxygen species or ROS), which provides a mechanism for defects in sensory signaling and contractility, culminating in abnormal urodynamic behavior. 2021-09-29 2021 /pmc/articles/PMC8527459/ /pubmed/34676378 http://dx.doi.org/10.20900/agmr20210018 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Article Birder, Lori A. Jackson, Edwin K. Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions |
title | Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions |
title_full | Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions |
title_fullStr | Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions |
title_full_unstemmed | Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions |
title_short | Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions |
title_sort | dysregulated purine metabolism contributes to age-associated lower urinary tract dysfunctions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527459/ https://www.ncbi.nlm.nih.gov/pubmed/34676378 http://dx.doi.org/10.20900/agmr20210018 |
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